TY  - JOUR
AU  - Krämer, Christina
AU  - Kohlheyer, Dietrich
TI  - Mikrobiologische Einzelzell-Phänotypencharakterisierung im Mikrochip
JO  - Biospektrum
VL  - 22
IS  - 1
SN  - 1868-6249
CY  - Heidelberg
PB  - Spektrum
M1  - FZJ-2016-01660
SP  - 48 - 50
PY  - 2016
AB  - Microbes adapt to environmental changes by DNA embedded mechanisms (e. g. resistance) or non-DNA based phenotypical differentiation (e. g. tolerance). Single-cell fluorescence imaging combined with environmental control by microfluidic devices helps to unravel phenotypical changes of single microbial cells in isogenic cell populations. Therefore, the intracellular implementation of fluorescent molecules by genetic modification or dynamic staining is essential for non-invasive live-cell imaging.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1007/s12268-016-0658-3
UR  - https://juser.fz-juelich.de/record/282926
ER  -