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000283460 1001_ $$0P:(DE-Juel1)144116$$aRudolph, Stephan$$b0
000283460 245__ $$aCompetitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity
000283460 260__ $$aLawrence, Kan.$$bPLoS$$c2016
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000283460 520__ $$aAlzheimer´s disease is the most prominent type of dementia and currently no causative treatment is available. According to recent studies, oligomeric species of the amyloid beta (Aβ) peptide appear to be the most toxic Aβ assemblies. Aβ monomers, however, may be not toxic per se and may even have a neuroprotective role. Here we describe a competitive mirror image phage display procedure that allowed us to identify preferentially Aβ1–42 monomer binding and thereby stabilizing peptides, which destabilize and thereby eliminate toxic oligomer species. One of the peptides, called Mosd1 (monomer specific d-peptide 1), was characterized in more detail. Mosd1 abolished oligomers from a mixture of Aβ1–42 species, reduced Aβ1–42 toxicity in cell culture, and restored the physiological phenotype in neuronal cells stably transfected with the gene coding for human amyloid precursor protein.
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000283460 7001_ $$0P:(DE-Juel1)145785$$aKlein, Antonia Nicole$$b1
000283460 7001_ $$0P:(DE-Juel1)131709$$aTusche, Markus$$b2$$ufzj
000283460 7001_ $$0P:(DE-Juel1)161502$$aSchlosser, Christine$$b3
000283460 7001_ $$0P:(DE-Juel1)164354$$aElfgen, Anne$$b4$$ufzj
000283460 7001_ $$0P:(DE-HGF)0$$aBrener, Oleksandr$$b5
000283460 7001_ $$0P:(DE-HGF)0$$aTeunissen, Charlotte$$b6
000283460 7001_ $$0P:(DE-Juel1)145165$$aGremer, Lothar$$b7$$ufzj
000283460 7001_ $$0P:(DE-HGF)0$$aFunke, Susanne Aileen$$b8
000283460 7001_ $$0P:(DE-Juel1)159137$$aKutzsche, Janine$$b9$$ufzj
000283460 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b10$$eCorresponding author$$ufzj
000283460 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0147470$$gVol. 11, no. 2, p. e0147470 -$$n2$$pe0147470 -$$tPLoS one$$v11$$x1932-6203$$y2016
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