TY  - JOUR
AU  - Rudolph, Stephan
AU  - Klein, Antonia Nicole
AU  - Tusche, Markus
AU  - Schlosser, Christine
AU  - Elfgen, Anne
AU  - Brener, Oleksandr
AU  - Teunissen, Charlotte
AU  - Gremer, Lothar
AU  - Funke, Susanne Aileen
AU  - Kutzsche, Janine
AU  - Willbold, Dieter
TI  - Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity
JO  - PLoS one
VL  - 11
IS  - 2
SN  - 1932-6203
CY  - Lawrence, Kan.
PB  - PLoS
M1  - FZJ-2016-01815
SP  - e0147470 -
PY  - 2016
AB  - Alzheimer´s disease is the most prominent type of dementia and currently no causative treatment is available. According to recent studies, oligomeric species of the amyloid beta (Aβ) peptide appear to be the most toxic Aβ assemblies. Aβ monomers, however, may be not toxic per se and may even have a neuroprotective role. Here we describe a competitive mirror image phage display procedure that allowed us to identify preferentially Aβ1–42 monomer binding and thereby stabilizing peptides, which destabilize and thereby eliminate toxic oligomer species. One of the peptides, called Mosd1 (monomer specific d-peptide 1), was characterized in more detail. Mosd1 abolished oligomers from a mixture of Aβ1–42 species, reduced Aβ1–42 toxicity in cell culture, and restored the physiological phenotype in neuronal cells stably transfected with the gene coding for human amyloid precursor protein.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000369550200041
C6  - pmid:26840229
DO  - DOI:10.1371/journal.pone.0147470
UR  - https://juser.fz-juelich.de/record/283460
ER  -