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000028485 0247_ $$2DOI$$a10.1038/ncb915
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000028485 084__ $$2WoS$$aCell Biology
000028485 1001_ $$0P:(DE-Juel1)VDB728$$aKaupp, U. B.$$b0$$uFZJ
000028485 245__ $$aThe signal flow and motor response controling chemotaxis of sea urchin sperm
000028485 260__ $$aNew York, NY$$bNature America$$c2003
000028485 300__ $$a109 - 117
000028485 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000028485 440_0 $$09481$$aNature Cell Biology$$v5$$x1465-7392
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000028485 520__ $$aThe signalling pathway and the behavioural strategy underlying chemotaxis of sperm are poorly understood. We have studied the cellular events and motor responses that mediate chemotaxis of sperm from the sea urchin Arbacia punctulata. Here we show that resact, a chemoattractant peptide, initiates a rapid and transient rise in the concentration of cyclic GMP, followed by a transient influx of Ca2+. The binding of a single resact molecule elicits a Ca2+ response, and 50-100 bound molecules saturate the response. The ability to register single molecules is reminiscent of the single-photon sensitivity of rod photoreceptors. Both resact and cyclic nucleotides cause a turn or brief tumbling in the swimming path of sperm. We conclude that a cGMP-mediated increase in the Ca2+ concentration induces the primary motor response of sperm to the chemoattractant.
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000028485 650_2 $$2MeSH$$aAnimals
000028485 650_2 $$2MeSH$$aCalcium: metabolism
000028485 650_2 $$2MeSH$$aChemotaxis: physiology
000028485 650_2 $$2MeSH$$aCyclic AMP: analogs & derivatives
000028485 650_2 $$2MeSH$$aCyclic AMP: metabolism
000028485 650_2 $$2MeSH$$aCyclic GMP: analogs & derivatives
000028485 650_2 $$2MeSH$$aCyclic GMP: metabolism
000028485 650_2 $$2MeSH$$aEgg Proteins: metabolism
000028485 650_2 $$2MeSH$$aGuanylate Cyclase
000028485 650_2 $$2MeSH$$aMale
000028485 650_2 $$2MeSH$$aMolecular Structure
000028485 650_2 $$2MeSH$$aProtein Binding
000028485 650_2 $$2MeSH$$aReceptors, Cell Surface: metabolism
000028485 650_2 $$2MeSH$$aSea Urchins: physiology
000028485 650_2 $$2MeSH$$aSignal Transduction: physiology
000028485 650_2 $$2MeSH$$aSperm Motility
000028485 650_2 $$2MeSH$$aSpermatozoa: cytology
000028485 650_2 $$2MeSH$$aSpermatozoa: metabolism
000028485 650_2 $$2MeSH$$aSpermatozoa: physiology
000028485 650_7 $$00$$2NLM Chemicals$$aEgg Proteins
000028485 650_7 $$00$$2NLM Chemicals$$aReceptors, Cell Surface
000028485 650_7 $$060-92-4$$2NLM Chemicals$$aCyclic AMP
000028485 650_7 $$07440-70-2$$2NLM Chemicals$$aCalcium
000028485 650_7 $$07665-99-8$$2NLM Chemicals$$aCyclic GMP
000028485 650_7 $$0EC 4.6.1.2$$2NLM Chemicals$$aGuanylate Cyclase
000028485 650_7 $$0EC 4.6.1.2$$2NLM Chemicals$$aresact protein, sea urchin
000028485 650_7 $$2WoSType$$aJ
000028485 7001_ $$0P:(DE-Juel1)VDB4898$$aSolzin, J.$$b1$$uFZJ
000028485 7001_ $$0P:(DE-Juel1)VDB18242$$aHildebrand, E.$$b2$$uFZJ
000028485 7001_ $$0P:(DE-HGF)0$$aBrown, J. E.$$b3
000028485 7001_ $$0P:(DE-Juel1)VDB18244$$aHelbig, A.$$b4$$uFZJ
000028485 7001_ $$0P:(DE-HGF)0$$aHagen, V.$$b5
000028485 7001_ $$0P:(DE-HGF)0$$aBeyermann, M.$$b6
000028485 7001_ $$0P:(DE-Juel1)VDB8457$$aPampaloni, F.$$b7$$uFZJ
000028485 7001_ $$0P:(DE-Juel1)131944$$aWeyand, I.$$b8$$uFZJ
000028485 773__ $$0PERI:(DE-600)1494945-3$$a10.1038/ncb915$$gVol. 5, p. 109 - 117$$p109 - 117$$q5<109 - 117$$tNature cell biology$$v5$$x1465-7392$$y2003
000028485 8567_ $$uhttp://dx.doi.org/10.1038/ncb915
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