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@ARTICLE{Kaupp:28485,
      author       = {Kaupp, U. B. and Solzin, J. and Hildebrand, E. and Brown,
                      J. E. and Helbig, A. and Hagen, V. and Beyermann, M. and
                      Pampaloni, F. and Weyand, I.},
      title        = {{T}he signal flow and motor response controling chemotaxis
                      of sea urchin sperm},
      journal      = {Nature cell biology},
      volume       = {5},
      issn         = {1465-7392},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {PreJuSER-28485},
      pages        = {109 - 117},
      year         = {2003},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The signalling pathway and the behavioural strategy
                      underlying chemotaxis of sperm are poorly understood. We
                      have studied the cellular events and motor responses that
                      mediate chemotaxis of sperm from the sea urchin Arbacia
                      punctulata. Here we show that resact, a chemoattractant
                      peptide, initiates a rapid and transient rise in the
                      concentration of cyclic GMP, followed by a transient influx
                      of Ca2+. The binding of a single resact molecule elicits a
                      Ca2+ response, and 50-100 bound molecules saturate the
                      response. The ability to register single molecules is
                      reminiscent of the single-photon sensitivity of rod
                      photoreceptors. Both resact and cyclic nucleotides cause a
                      turn or brief tumbling in the swimming path of sperm. We
                      conclude that a cGMP-mediated increase in the Ca2+
                      concentration induces the primary motor response of sperm to
                      the chemoattractant.},
      keywords     = {Animals / Calcium: metabolism / Chemotaxis: physiology /
                      Cyclic AMP: analogs $\&$ derivatives / Cyclic AMP:
                      metabolism / Cyclic GMP: analogs $\&$ derivatives / Cyclic
                      GMP: metabolism / Egg Proteins: metabolism / Guanylate
                      Cyclase / Male / Molecular Structure / Protein Binding /
                      Receptors, Cell Surface: metabolism / Sea Urchins:
                      physiology / Signal Transduction: physiology / Sperm
                      Motility / Spermatozoa: cytology / Spermatozoa: metabolism /
                      Spermatozoa: physiology / Egg Proteins (NLM Chemicals) /
                      Receptors, Cell Surface (NLM Chemicals) / Cyclic AMP (NLM
                      Chemicals) / Calcium (NLM Chemicals) / Cyclic GMP (NLM
                      Chemicals) / Guanylate Cyclase (NLM Chemicals) / resact
                      protein, sea urchin (NLM Chemicals) / J (WoSType)},
      cin          = {IBI-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB57},
      pnm          = {Neurowissenschaften},
      pid          = {G:(DE-Juel1)FUEK255},
      shelfmark    = {Cell Biology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:12563276},
      UT           = {WOS:000180802100010},
      doi          = {10.1038/ncb915},
      url          = {https://juser.fz-juelich.de/record/28485},
}