Gast ::
| Hauptseite > Publikationsdatenbank > The signal flow and motor response controling chemotaxis of sea urchin sperm > print |
| Hauptseite > Publikationsdatenbank > The signal flow and motor response controling chemotaxis of sea urchin sperm > print |
| 001 | 28485 | ||
| 005 | 20200402210451.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:12563276 |
| 024 | 7 | _ | |2 DOI |a 10.1038/ncb915 |
| 024 | 7 | _ | |2 WOS |a WOS:000180802100010 |
| 024 | 7 | _ | |a altmetric:21809622 |2 altmetric |
| 037 | _ | _ | |a PreJuSER-28485 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 084 | _ | _ | |2 WoS |a Cell Biology |
| 100 | 1 | _ | |a Kaupp, U. B. |b 0 |u FZJ |0 P:(DE-Juel1)VDB728 |
| 245 | _ | _ | |a The signal flow and motor response controling chemotaxis of sea urchin sperm |
| 260 | _ | _ | |a New York, NY |b Nature America |c 2003 |
| 300 | _ | _ | |a 109 - 117 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |a Nature Cell Biology |x 1465-7392 |0 9481 |v 5 |
| 500 | _ | _ | |a Record converted from VDB: 12.11.2012 |
| 520 | _ | _ | |a The signalling pathway and the behavioural strategy underlying chemotaxis of sperm are poorly understood. We have studied the cellular events and motor responses that mediate chemotaxis of sperm from the sea urchin Arbacia punctulata. Here we show that resact, a chemoattractant peptide, initiates a rapid and transient rise in the concentration of cyclic GMP, followed by a transient influx of Ca2+. The binding of a single resact molecule elicits a Ca2+ response, and 50-100 bound molecules saturate the response. The ability to register single molecules is reminiscent of the single-photon sensitivity of rod photoreceptors. Both resact and cyclic nucleotides cause a turn or brief tumbling in the swimming path of sperm. We conclude that a cGMP-mediated increase in the Ca2+ concentration induces the primary motor response of sperm to the chemoattractant. |
| 536 | _ | _ | |a Neurowissenschaften |c L01 |2 G:(DE-HGF) |0 G:(DE-Juel1)FUEK255 |x 0 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Animals |
| 650 | _ | 2 | |2 MeSH |a Calcium: metabolism |
| 650 | _ | 2 | |2 MeSH |a Chemotaxis: physiology |
| 650 | _ | 2 | |2 MeSH |a Cyclic AMP: analogs & derivatives |
| 650 | _ | 2 | |2 MeSH |a Cyclic AMP: metabolism |
| 650 | _ | 2 | |2 MeSH |a Cyclic GMP: analogs & derivatives |
| 650 | _ | 2 | |2 MeSH |a Cyclic GMP: metabolism |
| 650 | _ | 2 | |2 MeSH |a Egg Proteins: metabolism |
| 650 | _ | 2 | |2 MeSH |a Guanylate Cyclase |
| 650 | _ | 2 | |2 MeSH |a Male |
| 650 | _ | 2 | |2 MeSH |a Molecular Structure |
| 650 | _ | 2 | |2 MeSH |a Protein Binding |
| 650 | _ | 2 | |2 MeSH |a Receptors, Cell Surface: metabolism |
| 650 | _ | 2 | |2 MeSH |a Sea Urchins: physiology |
| 650 | _ | 2 | |2 MeSH |a Signal Transduction: physiology |
| 650 | _ | 2 | |2 MeSH |a Sperm Motility |
| 650 | _ | 2 | |2 MeSH |a Spermatozoa: cytology |
| 650 | _ | 2 | |2 MeSH |a Spermatozoa: metabolism |
| 650 | _ | 2 | |2 MeSH |a Spermatozoa: physiology |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Egg Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Receptors, Cell Surface |
| 650 | _ | 7 | |0 60-92-4 |2 NLM Chemicals |a Cyclic AMP |
| 650 | _ | 7 | |0 7440-70-2 |2 NLM Chemicals |a Calcium |
| 650 | _ | 7 | |0 7665-99-8 |2 NLM Chemicals |a Cyclic GMP |
| 650 | _ | 7 | |0 EC 4.6.1.2 |2 NLM Chemicals |a Guanylate Cyclase |
| 650 | _ | 7 | |0 EC 4.6.1.2 |2 NLM Chemicals |a resact protein, sea urchin |
| 650 | _ | 7 | |a J |2 WoSType |
| 700 | 1 | _ | |a Solzin, J. |b 1 |u FZJ |0 P:(DE-Juel1)VDB4898 |
| 700 | 1 | _ | |a Hildebrand, E. |b 2 |u FZJ |0 P:(DE-Juel1)VDB18242 |
| 700 | 1 | _ | |a Brown, J. E. |b 3 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Helbig, A. |b 4 |u FZJ |0 P:(DE-Juel1)VDB18244 |
| 700 | 1 | _ | |a Hagen, V. |b 5 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Beyermann, M. |b 6 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Pampaloni, F. |b 7 |u FZJ |0 P:(DE-Juel1)VDB8457 |
| 700 | 1 | _ | |a Weyand, I. |b 8 |u FZJ |0 P:(DE-Juel1)131944 |
| 773 | _ | _ | |a 10.1038/ncb915 |g Vol. 5, p. 109 - 117 |p 109 - 117 |q 5<109 - 117 |0 PERI:(DE-600)1494945-3 |t Nature cell biology |v 5 |y 2003 |x 1465-7392 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1038/ncb915 |
| 909 | C | O | |o oai:juser.fz-juelich.de:28485 |p VDB |
| 913 | 1 | _ | |k L01 |v Neurowissenschaften |l Funktion und Dysfunktion des Nervensystems |b Leben |0 G:(DE-Juel1)FUEK255 |x 0 |
| 914 | 1 | _ | |y 2003 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed |
| 920 | 1 | _ | |k IBI-1 |l Zelluläre Signalverarbeitung |d 31.12.2006 |g IBI |0 I:(DE-Juel1)VDB57 |x 0 |
| 970 | _ | _ | |a VDB:(DE-Juel1)22137 |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a ConvertedRecord |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a I:(DE-Juel1)ICS-4-20110106 |
| 980 | _ | _ | |a UNRESTRICTED |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-1-20200312 |
| 981 | _ | _ | |a I:(DE-Juel1)ICS-4-20110106 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|