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000029865 084__ $$2WoS$$aBiochemical Research Methods
000029865 084__ $$2WoS$$aChemistry, Medicinal
000029865 084__ $$2WoS$$aChemistry, Analytical
000029865 084__ $$2WoS$$aPharmacology & Pharmacy
000029865 1001_ $$0P:(DE-Juel1)VDB8872$$aStoll, T.$$b0$$uFZJ
000029865 245__ $$aApplication of n.c.a. 4-[18F]fluorophenol in diaryl ether syntheses of 2-(4-[18F]fluorophenoxy)-benzylamines
000029865 260__ $$aNew York, NY [u.a.]$$bWiley$$c2004
000029865 300__ $$a443 - 455
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000029865 440_0 $$03464$$aJournal of Labelled Compounds and Radiopharmaceuticals$$v47$$x0362-4803
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000029865 520__ $$aThe availability of no-carrier-added (n.c.a.) 4-[F-18]fluorophenol offers the possibility of introducing the 4-[F-18]fluorophenoxy moiety into potential radiopharmaceuticals. Besides alkyl-aryl ether synthesis using n.c.a. 4-[F-18]fluorophenol the diaryl ether coupling is an attractive synthetic method to enlarge the spectrum of interesting labelling procedures. As examples the syntheses of n.c.a. 2-(4-[F-18]fluorophenoxy)-N,N-dimethylbenzylamine and n.c.a. 2-(4-[F-18]fluorophenoxy)-N-methylbenzylamine were realized by an Ullmann ether synthesis of corresponding 2-bromobenzoic acid amides using tetrakis(acetonitrile)copper(I) hexafluorophosphate as catalyst and a subsequent reduction of the amides formed. The radiochemical yield of the coupling varied between 5 and 65% based on labelled 4-[F-18]fluorophenol. Both compounds are structural analogues of recently published radiotracers for imaging the serotonin reuptake transporter sites (SERT). However, in vitro binding assays of both molecules showed only a low affinity towards monoamine transporters. Copyright (C) 2004 John Wiley Sons, Ltd.
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000029865 65320 $$2Author$$adiaryl ether synthesis
000029865 65320 $$2Author$$aradiofluorination
000029865 65320 $$2Author$$an.c.a. 4-[F-18]fluorophenol
000029865 65320 $$2Author$$a2-(4[F-18]fluorophenoxy)N,N-dimethylbenzylamine
000029865 65320 $$2Author$$aSERT
000029865 650_7 $$2WoSType$$aJ
000029865 7001_ $$0P:(DE-Juel1)VDB6242$$aErmert, J.$$b1$$uFZJ
000029865 7001_ $$0P:(DE-HGF)0$$aOya, S.$$b2
000029865 7001_ $$0P:(DE-HGF)0$$aKung, H. F.$$b3
000029865 7001_ $$0P:(DE-Juel1)131816$$aCoenen, H. H.$$b4$$uFZJ
000029865 773__ $$0PERI:(DE-600)1491841-9$$a10.1002/jlcr.828$$gVol. 47, p. 443 - 455$$n7$$p443 - 455$$q47<443 - 455$$tJournal of labelled compounds and radiopharmaceuticals$$v47$$x0362-4803$$y2004
000029865 8567_ $$uhttp://dx.doi.org/10.1002/jlcr.828
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