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| Home > Publications database > Application of n.c.a. 4-[18F]fluorophenol in diaryl ether syntheses of 2-(4-[18F]fluorophenoxy)-benzylamines > print |
| Home > Publications database > Application of n.c.a. 4-[18F]fluorophenol in diaryl ether syntheses of 2-(4-[18F]fluorophenoxy)-benzylamines > print |
| 001 | 29865 | ||
| 005 | 20190625111338.0 | ||
| 024 | 7 | _ | |2 DOI |a 10.1002/jlcr.828 |
| 024 | 7 | _ | |2 WOS |a WOS:000222499000006 |
| 024 | 7 | _ | |2 ISSN |a 0362-4803 |
| 024 | 7 | _ | |a altmetric:21809984 |2 altmetric |
| 037 | _ | _ | |a PreJuSER-29865 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 540 |
| 084 | _ | _ | |2 WoS |a Biochemical Research Methods |
| 084 | _ | _ | |2 WoS |a Chemistry, Medicinal |
| 084 | _ | _ | |2 WoS |a Chemistry, Analytical |
| 084 | _ | _ | |2 WoS |a Pharmacology & Pharmacy |
| 100 | 1 | _ | |0 P:(DE-Juel1)VDB8872 |a Stoll, T. |b 0 |u FZJ |
| 245 | _ | _ | |a Application of n.c.a. 4-[18F]fluorophenol in diaryl ether syntheses of 2-(4-[18F]fluorophenoxy)-benzylamines |
| 260 | _ | _ | |a New York, NY [u.a.] |b Wiley |c 2004 |
| 300 | _ | _ | |a 443 - 455 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |0 3464 |a Journal of Labelled Compounds and Radiopharmaceuticals |v 47 |x 0362-4803 |
| 500 | _ | _ | |a Record converted from VDB: 12.11.2012 |
| 520 | _ | _ | |a The availability of no-carrier-added (n.c.a.) 4-[F-18]fluorophenol offers the possibility of introducing the 4-[F-18]fluorophenoxy moiety into potential radiopharmaceuticals. Besides alkyl-aryl ether synthesis using n.c.a. 4-[F-18]fluorophenol the diaryl ether coupling is an attractive synthetic method to enlarge the spectrum of interesting labelling procedures. As examples the syntheses of n.c.a. 2-(4-[F-18]fluorophenoxy)-N,N-dimethylbenzylamine and n.c.a. 2-(4-[F-18]fluorophenoxy)-N-methylbenzylamine were realized by an Ullmann ether synthesis of corresponding 2-bromobenzoic acid amides using tetrakis(acetonitrile)copper(I) hexafluorophosphate as catalyst and a subsequent reduction of the amides formed. The radiochemical yield of the coupling varied between 5 and 65% based on labelled 4-[F-18]fluorophenol. Both compounds are structural analogues of recently published radiotracers for imaging the serotonin reuptake transporter sites (SERT). However, in vitro binding assays of both molecules showed only a low affinity towards monoamine transporters. Copyright (C) 2004 John Wiley Sons, Ltd. |
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| 588 | _ | _ | |a Dataset connected to Web of Science |
| 650 | _ | 7 | |2 WoSType |a J |
| 653 | 2 | 0 | |2 Author |a diaryl ether synthesis |
| 653 | 2 | 0 | |2 Author |a radiofluorination |
| 653 | 2 | 0 | |2 Author |a n.c.a. 4-[F-18]fluorophenol |
| 653 | 2 | 0 | |2 Author |a 2-(4[F-18]fluorophenoxy)N,N-dimethylbenzylamine |
| 653 | 2 | 0 | |2 Author |a SERT |
| 700 | 1 | _ | |0 P:(DE-Juel1)VDB6242 |a Ermert, J. |b 1 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Oya, S. |b 2 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Kung, H. F. |b 3 |
| 700 | 1 | _ | |0 P:(DE-Juel1)131816 |a Coenen, H. H. |b 4 |u FZJ |
| 773 | _ | _ | |0 PERI:(DE-600)1491841-9 |a 10.1002/jlcr.828 |g Vol. 47, p. 443 - 455 |n 7 |p 443 - 455 |q 47<443 - 455 |t Journal of labelled compounds and radiopharmaceuticals |v 47 |x 0362-4803 |y 2004 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1002/jlcr.828 |
| 909 | C | O | |o oai:juser.fz-juelich.de:29865 |p VDB |
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| 914 | 1 | _ | |y 2004 |
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| 920 | 1 | _ | |0 I:(DE-Juel1)VDB53 |d 31.12.2006 |g INC |k INC |l Institut für Nuklearchemie |x 0 |
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