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000029871 0247_ $$2pmid$$apmid:12898626
000029871 0247_ $$2DOI$$a10.1002/cbic.200300631
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000029871 041__ $$aeng
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000029871 084__ $$2WoS$$aBiochemistry & Molecular Biology
000029871 084__ $$2WoS$$aChemistry, Medicinal
000029871 1001_ $$0P:(DE-Juel1)VDB15437$$aWiesehan, K.$$b0$$uFZJ
000029871 245__ $$aSelection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide A beta(1-42) by mirror image phage display
000029871 260__ $$aWeinheim$$bWiley-VCH$$c2003
000029871 300__ $$a748 - 753
000029871 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000029871 440_0 $$08962$$aChemBioChem$$v4$$x1439-4227
000029871 500__ $$aRecord converted from VDB: 12.11.2012
000029871 520__ $$aA mirror image phage display approach was used to identify novel and highly specific ligands for Alzheimer's disease amyloid peptide Abeta(1-42). A randomized 12-mer peptide library presented on M13 phages was screened for peptides with binding affinity for the mirror image of Abeta(1-42). After four rounds of selection and amplification the peptides were enriched with a dominating consensus sequence. The mirror image of the most representative peptide (D-pep) was shown to bind Abeta(1-42) with a dissociation constant in the submicromolar range. Furthermore, in brain tissue sections derived from patients that suffered from Alzheimer's disease, amyloid plaques and leptomeningeal vessels containing Abeta amyloid were stained specifically with a fluorescence-labeled derivative of D-pep. Fibrillar deposits derived from other amyloidosis were not labeled by D-pep. Possible applications of this novel and highly specific Abeta ligand in diagnosis and therapy of Alzheimer's disease are discussed.
000029871 536__ $$0G:(DE-Juel1)FUEK255$$2G:(DE-HGF)$$aNeurowissenschaften$$cL01$$x0
000029871 588__ $$aDataset connected to Web of Science, Pubmed
000029871 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000029871 650_2 $$2MeSH$$aAmino Acid Sequence
000029871 650_2 $$2MeSH$$aAmyloid beta-Peptides: chemistry
000029871 650_2 $$2MeSH$$aAmyloid beta-Peptides: genetics
000029871 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000029871 650_2 $$2MeSH$$aAmyloidosis: metabolism
000029871 650_2 $$2MeSH$$aBrain: metabolism
000029871 650_2 $$2MeSH$$aHumans
000029871 650_2 $$2MeSH$$aLigands
000029871 650_2 $$2MeSH$$aMolecular Sequence Data
000029871 650_2 $$2MeSH$$aPeptide Fragments: chemistry
000029871 650_2 $$2MeSH$$aPeptide Fragments: genetics
000029871 650_2 $$2MeSH$$aPeptide Fragments: metabolism
000029871 650_2 $$2MeSH$$aPeptide Library
000029871 650_2 $$2MeSH$$aPlaque, Amyloid: genetics
000029871 650_2 $$2MeSH$$aPlaque, Amyloid: metabolism
000029871 650_2 $$2MeSH$$aProtein Binding: physiology
000029871 650_7 $$00$$2NLM Chemicals$$aAmyloid beta-Peptides
000029871 650_7 $$00$$2NLM Chemicals$$aLigands
000029871 650_7 $$00$$2NLM Chemicals$$aPeptide Fragments
000029871 650_7 $$00$$2NLM Chemicals$$aPeptide Library
000029871 650_7 $$00$$2NLM Chemicals$$aamyloid beta-protein (1-40)
000029871 650_7 $$2WoSType$$aJ
000029871 65320 $$2Author$$aAlzheimer's disease
000029871 65320 $$2Author$$aamyloid peptide
000029871 65320 $$2Author$$aenantiomers
000029871 65320 $$2Author$$aligand design
000029871 65320 $$2Author$$aphage display
000029871 7001_ $$0P:(DE-HGF)0$$aBuder, K.$$b1
000029871 7001_ $$0P:(DE-HGF)0$$aLinke, R. P.$$b2
000029871 7001_ $$0P:(DE-HGF)0$$aPatt, S.$$b3
000029871 7001_ $$0P:(DE-Juel1)VDB21601$$aStoldt, M.$$b4$$uFZJ
000029871 7001_ $$0P:(DE-HGF)0$$aUnger, E.$$b5
000029871 7001_ $$0P:(DE-HGF)0$$aSchmitt, B.$$b6
000029871 7001_ $$0P:(DE-HGF)0$$aBucci, E.$$b7
000029871 7001_ $$0P:(DE-Juel1)132029$$aWillbold, D.$$b8$$uFZJ
000029871 773__ $$0PERI:(DE-600)2020469-3$$a10.1002/cbic.200300631$$gVol. 4, p. 748 - 753$$p748 - 753$$q4<748 - 753$$tChemBioChem$$v4$$x1439-4227$$y2003
000029871 8567_ $$uhttp://dx.doi.org/10.1002/cbic.200300631
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000029871 9141_ $$y2003
000029871 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000029871 9201_ $$0I:(DE-Juel1)VDB58$$d31.12.2006$$gIBI$$kIBI-2$$lBiologische Strukturforschung$$x0
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