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@ARTICLE{Wiesehan:29871,
      author       = {Wiesehan, K. and Buder, K. and Linke, R. P. and Patt, S.
                      and Stoldt, M. and Unger, E. and Schmitt, B. and Bucci, E.
                      and Willbold, D.},
      title        = {{S}election of {D}-amino-acid peptides that bind to
                      {A}lzheimer's disease amyloid peptide {A} beta(1-42) by
                      mirror image phage display},
      journal      = {ChemBioChem},
      volume       = {4},
      issn         = {1439-4227},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {PreJuSER-29871},
      pages        = {748 - 753},
      year         = {2003},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {A mirror image phage display approach was used to identify
                      novel and highly specific ligands for Alzheimer's disease
                      amyloid peptide Abeta(1-42). A randomized 12-mer peptide
                      library presented on M13 phages was screened for peptides
                      with binding affinity for the mirror image of Abeta(1-42).
                      After four rounds of selection and amplification the
                      peptides were enriched with a dominating consensus sequence.
                      The mirror image of the most representative peptide (D-pep)
                      was shown to bind Abeta(1-42) with a dissociation constant
                      in the submicromolar range. Furthermore, in brain tissue
                      sections derived from patients that suffered from
                      Alzheimer's disease, amyloid plaques and leptomeningeal
                      vessels containing Abeta amyloid were stained specifically
                      with a fluorescence-labeled derivative of D-pep. Fibrillar
                      deposits derived from other amyloidosis were not labeled by
                      D-pep. Possible applications of this novel and highly
                      specific Abeta ligand in diagnosis and therapy of
                      Alzheimer's disease are discussed.},
      keywords     = {Alzheimer Disease: metabolism / Amino Acid Sequence /
                      Amyloid beta-Peptides: chemistry / Amyloid beta-Peptides:
                      genetics / Amyloid beta-Peptides: metabolism / Amyloidosis:
                      metabolism / Brain: metabolism / Humans / Ligands /
                      Molecular Sequence Data / Peptide Fragments: chemistry /
                      Peptide Fragments: genetics / Peptide Fragments: metabolism
                      / Peptide Library / Plaque, Amyloid: genetics / Plaque,
                      Amyloid: metabolism / Protein Binding: physiology / Amyloid
                      beta-Peptides (NLM Chemicals) / Ligands (NLM Chemicals) /
                      Peptide Fragments (NLM Chemicals) / Peptide Library (NLM
                      Chemicals) / amyloid beta-protein (1-40) (NLM Chemicals) / J
                      (WoSType)},
      cin          = {IBI-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)VDB58},
      pnm          = {Neurowissenschaften},
      pid          = {G:(DE-Juel1)FUEK255},
      shelfmark    = {Biochemistry $\&$ Molecular Biology / Chemistry, Medicinal},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:12898626},
      UT           = {WOS:000184660400010},
      doi          = {10.1002/cbic.200300631},
      url          = {https://juser.fz-juelich.de/record/29871},
}