% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Lalah:29975,
      author       = {Lalah, J. O. and Schramm, K.-W. and Severin, G. F. and
                      Lenoir, D. and Henkelmann, F. A. and Behechti, A. and
                      Günther, K. and Kettrup, A.},
      title        = {{I}n vivo metabolism and organ distribution of a branched
                      14{C}-nonylphenol isomer in pond snails, {L}ymnaea stagnalis
                      {L}.},
      journal      = {Aquatic toxicology},
      volume       = {62},
      issn         = {0166-445X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-29975},
      pages        = {305 - 319},
      year         = {2003},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The branched isomers of p-nonylphenol (NP) are perceived to
                      be more resistant to biodegradation in aquatic environments
                      as well as to have more estrogen-like toxicity than the
                      straight chain isomers. By use of GC-MS, some of them have
                      been identified and found to exist in higher concentrations
                      in the isomeric compound mixture than the straight chain
                      isomers. The investigations of the distribution and
                      metabolism of these branched isomers in aquatic organisms
                      are therefore considered to be important in understanding
                      the mechanisms of toxicity of NP. A single tertiary isomer
                      of NP, 4(3'-,6'-dimethyl-3'-heptyl)-phenol, was synthesized
                      in the laboratory and used in in vivo studies of its organ
                      distribution and metabolism in Lymnaea stagnalis L.,
                      following a constant exposure of the organisms to C-14-NP
                      isomer in water over a period of 8 days at an average
                      exposure concentration of 105 ppb (range: 93-116 ppb). The
                      results obtained clearly showed the distribution and
                      bioconcentration of the isomer residues in various internal
                      organs of Lymnaea after uptake in water and food. Analysis
                      of the extracts of the organ tissues and faeces by HPLC and
                      GC- MS after digestion with Pankreatin/beta-glucuronidase
                      and nitric acid, respectively, showed that the isomer was
                      metabolized by conjugation to glucuronic acid and
                      hydroxylation to a catechol. The findings from these studies
                      and their implications in the biotransformation and
                      estrogenicity of NP in Lymnaea stagnalis L. are further
                      discussed in detail in this paper. (C) 2002 Elsevier Science
                      B.V. All rights reserved.},
      keywords     = {J (WoSType)},
      cin          = {ICG-III},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB49},
      pnm          = {Chemie und Dynamik der Geo-Biosphäre},
      pid          = {G:(DE-Juel1)FUEK257},
      shelfmark    = {Marine $\&$ Freshwater Biology / Toxicology},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000181265200004},
      doi          = {10.1016/S0166-445X(02)00106-6},
      url          = {https://juser.fz-juelich.de/record/29975},
}