Hauptseite > Publikationsdatenbank > In vivo metabolism and organ distribution of a branched 14C-nonylphenol isomer in pond snails, Lymnaea stagnalis L. > print

001     29975
005     20180210123025.0
024 7 _ |2 DOI
|a 10.1016/S0166-445X(02)00106-6
024 7 _ |2 WOS
|a WOS:000181265200004
037 _ _ |a PreJuSER-29975
041 _ _ |a eng
082 _ _ |a 570
084 _ _ |2 WoS
|a Marine & Freshwater Biology
084 _ _ |2 WoS
|a Toxicology
100 1 _ |a Lalah, J. O.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a In vivo metabolism and organ distribution of a branched 14C-nonylphenol isomer in pond snails, Lymnaea stagnalis L.
260 _ _ |a Amsterdam [u.a.]
|b Elsevier Science
|c 2003
300 _ _ |a 305 - 319
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Aquatic Toxicology
|x 0166-445X
|0 9645
|v 62
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a The branched isomers of p-nonylphenol (NP) are perceived to be more resistant to biodegradation in aquatic environments as well as to have more estrogen-like toxicity than the straight chain isomers. By use of GC-MS, some of them have been identified and found to exist in higher concentrations in the isomeric compound mixture than the straight chain isomers. The investigations of the distribution and metabolism of these branched isomers in aquatic organisms are therefore considered to be important in understanding the mechanisms of toxicity of NP. A single tertiary isomer of NP, 4(3'-,6'-dimethyl-3'-heptyl)-phenol, was synthesized in the laboratory and used in in vivo studies of its organ distribution and metabolism in Lymnaea stagnalis L., following a constant exposure of the organisms to C-14-NP isomer in water over a period of 8 days at an average exposure concentration of 105 ppb (range: 93-116 ppb). The results obtained clearly showed the distribution and bioconcentration of the isomer residues in various internal organs of Lymnaea after uptake in water and food. Analysis of the extracts of the organ tissues and faeces by HPLC and GC- MS after digestion with Pankreatin/beta-glucuronidase and nitric acid, respectively, showed that the isomer was metabolized by conjugation to glucuronic acid and hydroxylation to a catechol. The findings from these studies and their implications in the biotransformation and estrogenicity of NP in Lymnaea stagnalis L. are further discussed in detail in this paper. (C) 2002 Elsevier Science B.V. All rights reserved.
536 _ _ |a Chemie und Dynamik der Geo-Biosphäre
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588 _ _ |a Dataset connected to Web of Science
650 _ 7 |a J
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653 2 0 |2 Author
|a branched p-nonylphenol isomer
653 2 0 |2 Author
|a metabolism
653 2 0 |2 Author
|a Lymnaea stagnalis L
700 1 _ |a Schramm, K.-W.
|b 1
|0 P:(DE-HGF)0
700 1 _ |a Severin, G. F.
|b 2
|0 P:(DE-HGF)0
700 1 _ |a Lenoir, D.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Henkelmann, F. A.
|b 4
|0 P:(DE-HGF)0
700 1 _ |a Behechti, A.
|b 5
|0 P:(DE-HGF)0
700 1 _ |a Günther, K.
|b 6
|u FZJ
|0 P:(DE-Juel1)129325
700 1 _ |a Kettrup, A.
|b 7
|0 P:(DE-HGF)0
773 _ _ |a 10.1016/S0166-445X(02)00106-6
|g Vol. 62, p. 305 - 319
|p 305 - 319
|q 62<305 - 319
|0 PERI:(DE-600)1496065-5
|t Aquatic toxicology
|v 62
|y 2003
|x 0166-445X
856 7 _ |u http://dx.doi.org/10.1016/S0166-445X(02)00106-6
909 C O |o oai:juser.fz-juelich.de:29975
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913 1 _ |k U01
|v Chemie und Dynamik der Geo-Biosphäre
|l Chemie und Dynamik der Geo-Biosphäre
|b Environment (Umwelt)
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914 1 _ |y 2003
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |k ICG-III
|l Phytosphäre
|d 31.12.2006
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980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)IBG-2-20101118
981 _ _ |a I:(DE-Juel1)ICG-3-20090406

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