% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Briese:30238,
      author       = {Briese, L. and Willbold, D.},
      title        = {{S}tructure determination of human {L}ck unique and {SH}3
                      domains by nuclear magnetic resonance spectroscopy},
      journal      = {BMC structural biology},
      volume       = {3},
      issn         = {1472-6807},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {PreJuSER-30238},
      pages        = {3},
      year         = {2003},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Protein tyrosine kinases are involved in signal
                      transduction pathways that regulate cell growth,
                      differentiation, activation and transformation. Human
                      lymphocyte specific kinase (Lck) is a 56 kDa protein
                      involved in T-cell- and IL2-receptor signaling.
                      Three-dimensional structures are known for SH3, SH2 and
                      kinase domains of Lck as well as for other tyrosine kinases.
                      No structure is known for the unique domain of any Src-type
                      tyrosine kinase.Lck(1-120) comprising unique and SH3 domains
                      was structurally investigated by nuclear magnetic resonance
                      spectroscopy. We found the unique domain, in contrast to the
                      SH3 part, to have basically no defined structural elements.
                      The solution structure of the SH3 part could be determined
                      with very high precision. It does not show significant
                      differences to Lck SH3 in the absence of the unique domain.
                      Minor differences were observed to the X-ray structure of
                      Lck SH3.The unique domain of Lck does not contain any
                      defined structure elements in the absence of ligands and
                      membranes. Presence of the unique domain is not relevant to
                      the three-dimensional structure of the Lck SH3 domain.},
      keywords     = {Crystallography, X-Ray / Humans / Lymphocyte Specific
                      Protein Tyrosine Kinase p56(lck): chemistry / Models,
                      Molecular / Nuclear Magnetic Resonance, Biomolecular / src
                      Homology Domains / Lymphocyte Specific Protein Tyrosine
                      Kinase p56(lck) (NLM Chemicals)},
      cin          = {IBI-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB58},
      pnm          = {Neurowissenschaften},
      pid          = {G:(DE-Juel1)FUEK255},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:12734017},
      pmc          = {pmc:PMC156628},
      doi          = {10.1186/1472-6807-3-3},
      url          = {https://juser.fz-juelich.de/record/30238},
}