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001     30238
005     20200402210517.0
024 7 _ |a pmid:12734017
|2 pmid
024 7 _ |a pmc:PMC156628
|2 pmc
024 7 _ |a 10.1186/1472-6807-3-3
|2 DOI
037 _ _ |a PreJuSER-30238
041 _ _ |a eng
082 _ _ |a 570
100 1 _ |a Briese, L.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a Structure determination of human Lck unique and SH3 domains by nuclear magnetic resonance spectroscopy
260 _ _ |a London
|b BioMed Central
|c 2003
300 _ _ |a 3
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a BMC Structural Biology
|x 1472-6807
|0 9664
|v 3
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Protein tyrosine kinases are involved in signal transduction pathways that regulate cell growth, differentiation, activation and transformation. Human lymphocyte specific kinase (Lck) is a 56 kDa protein involved in T-cell- and IL2-receptor signaling. Three-dimensional structures are known for SH3, SH2 and kinase domains of Lck as well as for other tyrosine kinases. No structure is known for the unique domain of any Src-type tyrosine kinase.Lck(1-120) comprising unique and SH3 domains was structurally investigated by nuclear magnetic resonance spectroscopy. We found the unique domain, in contrast to the SH3 part, to have basically no defined structural elements. The solution structure of the SH3 part could be determined with very high precision. It does not show significant differences to Lck SH3 in the absence of the unique domain. Minor differences were observed to the X-ray structure of Lck SH3.The unique domain of Lck does not contain any defined structure elements in the absence of ligands and membranes. Presence of the unique domain is not relevant to the three-dimensional structure of the Lck SH3 domain.
536 _ _ |a Neurowissenschaften
|c L01
|2 G:(DE-HGF)
|0 G:(DE-Juel1)FUEK255
|x 0
588 _ _ |a Dataset connected to Pubmed
650 _ 2 |2 MeSH
|a Crystallography, X-Ray
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Lymphocyte Specific Protein Tyrosine Kinase p56(lck): chemistry
650 _ 2 |2 MeSH
|a Models, Molecular
650 _ 2 |2 MeSH
|a Nuclear Magnetic Resonance, Biomolecular
650 _ 2 |2 MeSH
|a src Homology Domains
650 _ 7 |0 EC 2.7.10.2
|2 NLM Chemicals
|a Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
700 1 _ |a Willbold, D.
|b 1
|u FZJ
|0 P:(DE-Juel1)132029
773 _ _ |a 10.1186/1472-6807-3-3
|g Vol. 3, p. 3
|p 3
|q 3<3
|0 PERI:(DE-600)2050440-8
|t BMC structural biology
|v 3
|y 2003
|x 1472-6807
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156628
909 C O |o oai:juser.fz-juelich.de:30238
|p VDB
913 1 _ |k L01
|v Neurowissenschaften
|l Funktion und Dysfunktion des Nervensystems
|b Leben
|0 G:(DE-Juel1)FUEK255
|x 0
914 1 _ |y 2003
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |k IBI-2
|l Biologische Strukturforschung
|d 31.12.2006
|g IBI
|0 I:(DE-Juel1)VDB58
|x 0
970 _ _ |a VDB:(DE-Juel1)27787
980 _ _ |a VDB
980 _ _ |a ConvertedRecord
980 _ _ |a journal
980 _ _ |a I:(DE-Juel1)ISB-2-20090406
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)ICS-6-20110106
981 _ _ |a I:(DE-Juel1)IBI-7-20200312
981 _ _ |a I:(DE-Juel1)ISB-2-20090406
981 _ _ |a I:(DE-Juel1)ICS-6-20110106

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