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@ARTICLE{Koenig:30442,
author = {Koenig, B. W. and Rogowski, M. and Louis, J. M.},
title = {{A} rapid method to attain isotope labeled small soluble
peptides for {NMR} studies},
journal = {Journal of biomolecular NMR},
volume = {26},
issn = {0925-2738},
address = {Dordrecht [u.a.]},
publisher = {Springer Science + Business Media B.V},
reportid = {PreJuSER-30442},
pages = {193 - 202},
year = {2003},
note = {Record converted from VDB: 12.11.2012},
abstract = {A widely applicable strategy is presented for efficient and
rapid production of small water soluble peptides expressed
as fusion proteins with the immunoglobulin-binding domain of
streptococcal protein G. A simple extraction and
purification scheme that includes a protease cleavage step
to release the target peptide is described. The yield of
authentic target peptide exceeds 10 mg per liter of culture.
Production of U-C-13, N-15 and highly deuterated U-C-13,
N-15 isotope labeled peptide is demonstrated for the 11
residue S2 peptide, corresponding to the C-terminus of the
alpha-subunit of transducin, and the coiled coil
trimerization domain from cartilage matrix protein (CMPcc),
respectively. Heteronuclear two-dimensional NMR spectra are
used for initial peptide characterization.},
keywords = {J (WoSType)},
cin = {IBI-2},
ddc = {570},
cid = {I:(DE-Juel1)VDB58},
pnm = {Neurowissenschaften},
pid = {G:(DE-Juel1)FUEK255},
shelfmark = {Biochemistry $\&$ Molecular Biology / Spectroscopy},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000183041200001},
doi = {10.1023/A:1023887412387},
url = {https://juser.fz-juelich.de/record/30442},
}