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@ARTICLE{Menezes:32545,
      author       = {Menezes, R. A. and Amuel, C. and Engels, R. and
                      Gengenbacher, U. and Labahn, J. and Hollenberg, E. M.},
      title        = {{S}ites for {I}nteraction between {G}al80p and {G}al1p in
                      {K}luyveromyces latis: {S}tructural {M}odel of
                      {G}alactokinase based on {H}omology to the {GHMP} {P}rotein
                      {F}amily},
      journal      = {Journal of molecular biology},
      volume       = {333},
      issn         = {0022-2836},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {PreJuSER-32545},
      pages        = {479 - 492},
      year         = {2003},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The induction of transcription of the galactose genes in
                      yeast involves the galactose-dependent binding of ScGal3p
                      (in Saccharomyces cerevisiae) or KlGal1p (in Kluyveromyces
                      lactis) to Gal80p. This binding abrogates Gal80's inhibitory
                      effect on the activation domain of Gal4p, which can then
                      activate transcription. Here, we describe the isolation and
                      characterization of new interaction mutants of K. lactis
                      GAL1 and GAL80 using a two-hybrid screen. We present the
                      first structural model for Gal1p to be based on the
                      published crystal structures of other proteins belonging to
                      the GHMP (galactokinase, homoserine kinase, mevalonate
                      kinase and phosphomevalonate kinase) kinase family and our
                      own X-ray diffraction data of Gal1p crystals at 3 Angstrom
                      resolution.The locations of the various mutations in the
                      modelled Gal1p structure identify domains involved in the
                      interaction with Gal80p and provide a structural explanation
                      for the phenotype of constitutive GAL1 mutations. (C) 2003
                      Elsevier Ltd. All rights reserved.},
      keywords     = {J (WoSType)},
      cin          = {IBI-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB58},
      pnm          = {Neurowissenschaften},
      pid          = {G:(DE-Juel1)FUEK255},
      shelfmark    = {Biochemistry $\&$ Molecular Biology},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000186102000001},
      doi          = {10.1016/j.jmb.2003.08.034},
      url          = {https://juser.fz-juelich.de/record/32545},
}