%0 Thesis
%A Wolfram, Evelyn P.
%T Parallele Substratkontrolle in Bioreaktoren mit geringem Volumen
%V 3982
%N Juel-3982
%@ 0944-2952
%I Techn. Univ. München
%V Dr. (Univ.)
%C Jülich
%M PreJuSER-33332
%M Juel-3982
%B Berichte des Forschungszentrums Jülich
%P VII, 194 p.
%D 2002
%Z Record converted from VDB: 12.11.2012
%Z München, Techn. Univ., Diss., 2001
%X In the first developmental phase of microbial processes, relevant parameters for reaction engineering are investigated and optimized with parallel experiments in small reactors (shake flask scale) . Substrate concentrations are central process parameters . Their control might help to increase efficiency and quality of this developmental phase . Thus, a parallel, automatic and sterile sampling technique wich hollow fiber membranes was developed that suits the Small reaction volume. The parallel sampling modules were connected to a Substrate analysis system. The combination of the analytical technique with a controller and a precise microdosing System for Substrate closed the control loop. The prototype device was characterized and its suitability for online monitoring and control of bioprocesses confirmed . This technique allows for the firnt time online measurement and control of Substrate concentrations in parallel bioreactions (i.e . with Escherichia coli) wich measuring raten of the order of minutes
%F PUB:(DE-HGF)11 ; PUB:(DE-HGF)3
%9 Dissertation / PhD ThesisBook
%U https://juser.fz-juelich.de/record/33332