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000033332 0881_ $$aJuel-3982
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000033332 1001_ $$0P:(DE-Juel1)VDB1802$$aWolfram, Evelyn P.$$b0$$eCorresponding author$$uFZJ
000033332 245__ $$aParallele Substratkontrolle in Bioreaktoren mit geringem Volumen
000033332 260__ $$aJülich$$bForschungszentrum Jülich GmbH Zenralbibliothek, Verlag$$c2002
000033332 300__ $$aVII, 194 p.
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000033332 4900_ $$0PERI:(DE-600)2414853-2$$84709$$aBerichte des Forschungszentrums Jülich$$v3982$$x0944-2952
000033332 502__ $$aMünchen, Techn. Univ., Diss., 2001$$bDr. (Univ.)$$cTechn. Univ. München$$d2001
000033332 500__ $$aRecord converted from VDB: 12.11.2012
000033332 520__ $$aIn the first developmental phase of microbial processes, relevant parameters for reaction engineering are investigated and optimized with parallel experiments in small reactors (shake flask scale) . Substrate concentrations are central process parameters . Their control might help to increase efficiency and quality of this developmental phase . Thus, a parallel, automatic and sterile sampling technique wich hollow fiber membranes was developed that suits the Small reaction volume. The parallel sampling modules were connected to a Substrate analysis system. The combination of the analytical technique with a controller and a precise microdosing System for Substrate closed the control loop. The prototype device was characterized and its suitability for online monitoring and control of bioprocesses confirmed . This technique allows for the firnt time online measurement and control of Substrate concentrations in parallel bioreactions (i.e . with Escherichia coli) wich measuring raten of the order of minutes
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000033332 655_7 $$aHochschulschrift$$xDissertation (Univ.)
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000033332 9131_ $$0G:(DE-Juel1)FUEK93$$bLebenswissenschaften$$k41.40.0$$lBiotechnologie$$vVerfahrenstechnik zur mikrobiellen Gewinnung  von Primärmetaboliten$$x0
000033332 9201_ $$0I:(DE-Juel1)VDB56$$gIBT$$kIBT-2$$lBiotechnologie 2$$x0$$zab 31.10.10 weitergeführt IBG-1
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