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@PHDTHESIS{Wolfram:33332,
      author       = {Wolfram, Evelyn P.},
      title        = {{P}arallele {S}ubstratkontrolle in {B}ioreaktoren mit
                      geringem {V}olumen},
      volume       = {3982},
      issn         = {0944-2952},
      school       = {Techn. Univ. München},
      type         = {Dr. (Univ.)},
      address      = {Jülich},
      publisher    = {Forschungszentrum Jülich GmbH Zenralbibliothek, Verlag},
      reportid     = {PreJuSER-33332, Juel-3982},
      series       = {Berichte des Forschungszentrums Jülich},
      pages        = {VII, 194 p.},
      year         = {2002},
      note         = {Record converted from VDB: 12.11.2012; München, Techn.
                      Univ., Diss., 2001},
      abstract     = {In the first developmental phase of microbial processes,
                      relevant parameters for reaction engineering are
                      investigated and optimized with parallel experiments in
                      small reactors (shake flask scale) . Substrate
                      concentrations are central process parameters . Their
                      control might help to increase efficiency and quality of
                      this developmental phase . Thus, a parallel, automatic and
                      sterile sampling technique wich hollow fiber membranes was
                      developed that suits the Small reaction volume. The parallel
                      sampling modules were connected to a Substrate analysis
                      system. The combination of the analytical technique with a
                      controller and a precise microdosing System for Substrate
                      closed the control loop. The prototype device was
                      characterized and its suitability for online monitoring and
                      control of bioprocesses confirmed . This technique allows
                      for the firnt time online measurement and control of
                      Substrate concentrations in parallel bioreactions (i.e .
                      with Escherichia coli) wich measuring raten of the order of
                      minutes},
      cin          = {IBT-2},
      cid          = {I:(DE-Juel1)VDB56},
      pnm          = {Verfahrenstechnik zur mikrobiellen Gewinnung von
                      Primärmetaboliten},
      pid          = {G:(DE-Juel1)FUEK93},
      typ          = {PUB:(DE-HGF)11 / PUB:(DE-HGF)3},
      url          = {https://juser.fz-juelich.de/record/33332},
}