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000003375 0247_ $$2DOI$$a10.1104/pp.109.136036
000003375 0247_ $$2WOS$$aWOS:000268696800021
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000003375 037__ $$aPreJuSER-3375
000003375 041__ $$aeng
000003375 082__ $$a580
000003375 084__ $$2WoS$$aPlant Sciences
000003375 1001_ $$0P:(DE-HGF)0$$aRahmani, F.$$b0
000003375 245__ $$aSucrose control of translation mediated by an upstream open reading frame-encoded peptide 1[W][OA]
000003375 260__ $$aRockville, Md.: Soc.$$bJSTOR$$c2009
000003375 300__ $$a1356 - 1367
000003375 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
000003375 3367_ $$2DataCite$$aOutput Types/Journal article
000003375 3367_ $$00$$2EndNote$$aJournal Article
000003375 3367_ $$2BibTeX$$aARTICLE
000003375 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000003375 3367_ $$2DRIVER$$aarticle
000003375 440_0 $$04987$$aPlant Physiology$$v150$$x0032-0889
000003375 500__ $$aThis work was supported by the Centre for BioSystems Genomics and by the Dutch Research Council.
000003375 520__ $$aRegulation of gene expression through translational control is common in many organisms. The Arabidopsis (Arabidopsis thaliana) transcription factor bZIP11 is translational repressed in response to sucrose (Suc), resulting in Suc-regulated changes in amino acid metabolism. The 5' leader of the bZIP11 mRNA harbors several upstream open reading frames (uORFs), of which the second uORF is well conserved among bZIP11 homologous genes. The uORF2 element encodes a Suc control peptide (SC-peptide) of 28 residues that is sufficient for imposing Suc-induced repression of translation (SIRT) on a heterologous mRNA. Detailed analysis of the SC-peptide suggests that it functions as an attenuator peptide. Results suggest that the SC-peptide inhibits bZIP11 translation in response to high Suc levels by stalling the ribosome on the mRNA. The conserved noncanonical AUG contexts of bZIP11 uORFs allow inefficient translational initiation of the uORF, resulting in translation initiation of the scanning ribosome at the AUG codon of the bZIP11 main ORF. The results presented show that Suc-dependent signaling mediates differential translation of mRNAs containing SC-peptides encoding uORFs.
000003375 536__ $$0G:(DE-Juel1)FUEK407$$2G:(DE-HGF)$$aTerrestrische Umwelt$$cP24$$x0
000003375 588__ $$aDataset connected to Web of Science, Pubmed
000003375 650_2 $$2MeSH$$aAmino Acid Sequence
000003375 650_2 $$2MeSH$$aArabidopsis: drug effects
000003375 650_2 $$2MeSH$$aArabidopsis: genetics
000003375 650_2 $$2MeSH$$aArabidopsis Proteins: chemistry
000003375 650_2 $$2MeSH$$aArabidopsis Proteins: genetics
000003375 650_2 $$2MeSH$$aArabidopsis Proteins: metabolism
000003375 650_2 $$2MeSH$$aBase Sequence
000003375 650_2 $$2MeSH$$aBasic-Leucine Zipper Transcription Factors: chemistry
000003375 650_2 $$2MeSH$$aBasic-Leucine Zipper Transcription Factors: genetics
000003375 650_2 $$2MeSH$$aBasic-Leucine Zipper Transcription Factors: metabolism
000003375 650_2 $$2MeSH$$aConserved Sequence
000003375 650_2 $$2MeSH$$aGene Expression Regulation, Plant: drug effects
000003375 650_2 $$2MeSH$$aMolecular Sequence Data
000003375 650_2 $$2MeSH$$aOpen Reading Frames
000003375 650_2 $$2MeSH$$aProtein Biosynthesis: drug effects
000003375 650_2 $$2MeSH$$aRNA, Messenger: chemistry
000003375 650_2 $$2MeSH$$aSequence Analysis, RNA
000003375 650_2 $$2MeSH$$aSucrose: pharmacology
000003375 650_7 $$00$$2NLM Chemicals$$aATB2 protein, Arabidopsis
000003375 650_7 $$00$$2NLM Chemicals$$aArabidopsis Proteins
000003375 650_7 $$00$$2NLM Chemicals$$aBasic-Leucine Zipper Transcription Factors
000003375 650_7 $$00$$2NLM Chemicals$$aRNA, Messenger
000003375 650_7 $$057-50-1$$2NLM Chemicals$$aSucrose
000003375 650_7 $$2WoSType$$aJ
000003375 7001_ $$0P:(DE-HGF)0$$aHummel, M.$$b1
000003375 7001_ $$0P:(DE-HGF)0$$aSchuurmans, J.$$b2
000003375 7001_ $$0P:(DE-Juel1)129420$$aWiese-Klinkenberg, A.$$b3$$uFZJ
000003375 7001_ $$0P:(DE-HGF)0$$aSmeekens, S.$$b4
000003375 7001_ $$0P:(DE-HGF)0$$aHanson, J.$$b5
000003375 773__ $$0PERI:(DE-600)2004346-6$$a10.1104/pp.109.136036$$gVol. 150, p. 1356 - 1367$$p1356 - 1367$$q150<1356 - 1367$$tPlant physiology$$v150$$x0032-0889$$y2009
000003375 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705056
000003375 8564_ $$uhttps://juser.fz-juelich.de/record/3375/files/FZJ-3375.pdf$$yRestricted$$zPublished final document.
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