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@ARTICLE{Rahmani:3375,
      author       = {Rahmani, F. and Hummel, M. and Schuurmans, J. and
                      Wiese-Klinkenberg, A. and Smeekens, S. and Hanson, J.},
      title        = {{S}ucrose control of translation mediated by an upstream
                      open reading frame-encoded peptide 1[{W}][{OA}]},
      journal      = {Plant physiology},
      volume       = {150},
      issn         = {0032-0889},
      address      = {Rockville, Md.: Soc.},
      publisher    = {JSTOR},
      reportid     = {PreJuSER-3375},
      pages        = {1356 - 1367},
      year         = {2009},
      note         = {This work was supported by the Centre for BioSystems
                      Genomics and by the Dutch Research Council.},
      abstract     = {Regulation of gene expression through translational control
                      is common in many organisms. The Arabidopsis (Arabidopsis
                      thaliana) transcription factor bZIP11 is translational
                      repressed in response to sucrose (Suc), resulting in
                      Suc-regulated changes in amino acid metabolism. The 5'
                      leader of the bZIP11 mRNA harbors several upstream open
                      reading frames (uORFs), of which the second uORF is well
                      conserved among bZIP11 homologous genes. The uORF2 element
                      encodes a Suc control peptide (SC-peptide) of 28 residues
                      that is sufficient for imposing Suc-induced repression of
                      translation (SIRT) on a heterologous mRNA. Detailed analysis
                      of the SC-peptide suggests that it functions as an
                      attenuator peptide. Results suggest that the SC-peptide
                      inhibits bZIP11 translation in response to high Suc levels
                      by stalling the ribosome on the mRNA. The conserved
                      noncanonical AUG contexts of bZIP11 uORFs allow inefficient
                      translational initiation of the uORF, resulting in
                      translation initiation of the scanning ribosome at the AUG
                      codon of the bZIP11 main ORF. The results presented show
                      that Suc-dependent signaling mediates differential
                      translation of mRNAs containing SC-peptides encoding uORFs.},
      keywords     = {Amino Acid Sequence / Arabidopsis: drug effects /
                      Arabidopsis: genetics / Arabidopsis Proteins: chemistry /
                      Arabidopsis Proteins: genetics / Arabidopsis Proteins:
                      metabolism / Base Sequence / Basic-Leucine Zipper
                      Transcription Factors: chemistry / Basic-Leucine Zipper
                      Transcription Factors: genetics / Basic-Leucine Zipper
                      Transcription Factors: metabolism / Conserved Sequence /
                      Gene Expression Regulation, Plant: drug effects / Molecular
                      Sequence Data / Open Reading Frames / Protein Biosynthesis:
                      drug effects / RNA, Messenger: chemistry / Sequence
                      Analysis, RNA / Sucrose: pharmacology / ATB2 protein,
                      Arabidopsis (NLM Chemicals) / Arabidopsis Proteins (NLM
                      Chemicals) / Basic-Leucine Zipper Transcription Factors (NLM
                      Chemicals) / RNA, Messenger (NLM Chemicals) / Sucrose (NLM
                      Chemicals) / J (WoSType)},
      cin          = {ICG-3},
      ddc          = {580},
      cid          = {I:(DE-Juel1)ICG-3-20090406},
      pnm          = {Terrestrische Umwelt},
      pid          = {G:(DE-Juel1)FUEK407},
      shelfmark    = {Plant Sciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19403731},
      pmc          = {pmc:PMC2705056},
      UT           = {WOS:000268696800021},
      doi          = {10.1104/pp.109.136036},
      url          = {https://juser.fz-juelich.de/record/3375},
}