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000003433 084__ $$2WoS$$aBiochemistry & Molecular Biology
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000003433 084__ $$2WoS$$aMedicine, Research & Experimental
000003433 1001_ $$0P:(DE-Juel1)129343$$aKastenholz, B.$$b0$$uFZJ
000003433 245__ $$aPlant metal chaperones: a novel perspective in dementia therapy
000003433 260__ $$aLondon [u.a.]$$bInforma Healthcare$$c2009
000003433 300__ $$a81 - 83
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000003433 440_0 $$020782$$aAmyloid The Journal of Protein Folding Disorders$$v16$$y2
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000003433 520__ $$aDys-homeostasis of copper metabolism and oxidative stress are major hallmarks in the brains of Alzheimer patients. Therefore, metal bioavailability and mechanisms of copper ion homeostasis throughout the body are crucial and potential targets for therapeutic agents. Many of the medications used or suggested, respectively, at present time, may either be toxic, reveal a lack of specificity or have unknown mechanisms of action in vivo. Metal chaperones from medicinal plants are proposed as medications that are relatively free from these disadvantages. Furthermore, these agents are a promising class of molecules for studies aimed at developing innovative and etiological treatments for protein-misfolding diseases, especially Alzheimer's disease.
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000003433 650_2 $$2MeSH$$aCopper: chemistry
000003433 650_2 $$2MeSH$$aCopper: metabolism
000003433 650_2 $$2MeSH$$aDementia: drug therapy
000003433 650_2 $$2MeSH$$aHomeostasis
000003433 650_2 $$2MeSH$$aHumans
000003433 650_2 $$2MeSH$$aMolecular Chaperones: chemistry
000003433 650_2 $$2MeSH$$aMolecular Chaperones: therapeutic use
000003433 650_2 $$2MeSH$$aOxidative Stress
000003433 650_2 $$2MeSH$$aPlants: chemistry
000003433 650_7 $$00$$2NLM Chemicals$$aMolecular Chaperones
000003433 650_7 $$07440-50-8$$2NLM Chemicals$$aCopper
000003433 650_7 $$2WoSType$$aJ
000003433 65320 $$2Author$$aMetal chaperones
000003433 65320 $$2Author$$aAlzheimer's disease
000003433 65320 $$2Author$$abiochemical impact
000003433 65320 $$2Author$$aSOD-1
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000003433 7001_ $$0P:(DE-HGF)0$$aGarfin, D.E.$$b1
000003433 7001_ $$0P:(DE-HGF)0$$aHorst, J.$$b2
000003433 7001_ $$0P:(DE-Juel1)129373$$aNagel, K. A.$$b3$$uFZJ
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000003433 8567_ $$uhttp://dx.doi.org/10.1080/13506120902879392
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