TY  - JOUR
AU  - Kastenholz, B.
AU  - Garfin, D.E.
AU  - Horst, J.
AU  - Nagel, K. A.
TI  - Plant metal chaperones: a novel perspective in dementia therapy
JO  - Amyloid
VL  - 16
SN  - 1350-6129
CY  - London [u.a.]
PB  - Informa Healthcare
M1  - PreJuSER-3433
SP  - 81 - 83
PY  - 2009
N1  - Record converted from VDB: 12.11.2012
AB  - Dys-homeostasis of copper metabolism and oxidative stress are major hallmarks in the brains of Alzheimer patients. Therefore, metal bioavailability and mechanisms of copper ion homeostasis throughout the body are crucial and potential targets for therapeutic agents. Many of the medications used or suggested, respectively, at present time, may either be toxic, reveal a lack of specificity or have unknown mechanisms of action in vivo. Metal chaperones from medicinal plants are proposed as medications that are relatively free from these disadvantages. Furthermore, these agents are a promising class of molecules for studies aimed at developing innovative and etiological treatments for protein-misfolding diseases, especially Alzheimer's disease.
KW  - Copper: chemistry
KW  - Copper: metabolism
KW  - Dementia: drug therapy
KW  - Homeostasis
KW  - Humans
KW  - Molecular Chaperones: chemistry
KW  - Molecular Chaperones: therapeutic use
KW  - Oxidative Stress
KW  - Plants: chemistry
KW  - Molecular Chaperones (NLM Chemicals)
KW  - Copper (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:20536399
UR  - <Go to ISI:>//WOS:000268681100003
DO  - DOI:10.1080/13506120902879392
UR  - https://juser.fz-juelich.de/record/3433
ER  -