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@ARTICLE{Kastenholz:3433,
author = {Kastenholz, B. and Garfin, D.E. and Horst, J. and Nagel, K.
A.},
title = {{P}lant metal chaperones: a novel perspective in dementia
therapy},
journal = {Amyloid},
volume = {16},
issn = {1350-6129},
address = {London [u.a.]},
publisher = {Informa Healthcare},
reportid = {PreJuSER-3433},
pages = {81 - 83},
year = {2009},
note = {Record converted from VDB: 12.11.2012},
abstract = {Dys-homeostasis of copper metabolism and oxidative stress
are major hallmarks in the brains of Alzheimer patients.
Therefore, metal bioavailability and mechanisms of copper
ion homeostasis throughout the body are crucial and
potential targets for therapeutic agents. Many of the
medications used or suggested, respectively, at present
time, may either be toxic, reveal a lack of specificity or
have unknown mechanisms of action in vivo. Metal chaperones
from medicinal plants are proposed as medications that are
relatively free from these disadvantages. Furthermore, these
agents are a promising class of molecules for studies aimed
at developing innovative and etiological treatments for
protein-misfolding diseases, especially Alzheimer's
disease.},
keywords = {Copper: chemistry / Copper: metabolism / Dementia: drug
therapy / Homeostasis / Humans / Molecular Chaperones:
chemistry / Molecular Chaperones: therapeutic use /
Oxidative Stress / Plants: chemistry / Molecular Chaperones
(NLM Chemicals) / Copper (NLM Chemicals) / J (WoSType)},
cin = {ICG-3},
ddc = {610},
cid = {I:(DE-Juel1)ICG-3-20090406},
pnm = {Terrestrische Umwelt},
pid = {G:(DE-Juel1)FUEK407},
shelfmark = {Biochemistry $\&$ Molecular Biology / Medicine, General
$\&$ Internal / Medicine, Research $\&$ Experimental},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:20536399},
UT = {WOS:000268681100003},
doi = {10.1080/13506120902879392},
url = {https://juser.fz-juelich.de/record/3433},
}