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024 7 _ |2 pmid
|a pmid:20536399
024 7 _ |2 DOI
|a 10.1080/13506120902879392
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037 _ _ |a PreJuSER-3433
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Biochemistry & Molecular Biology
084 _ _ |2 WoS
|a Medicine, General & Internal
084 _ _ |2 WoS
|a Medicine, Research & Experimental
100 1 _ |a Kastenholz, B.
|b 0
|u FZJ
|0 P:(DE-Juel1)129343
245 _ _ |a Plant metal chaperones: a novel perspective in dementia therapy
260 _ _ |a London [u.a.]
|b Informa Healthcare
|c 2009
300 _ _ |a 81 - 83
336 7 _ |a Journal Article
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336 7 _ |a article
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440 _ 0 |a Amyloid The Journal of Protein Folding Disorders
|0 20782
|y 2
|v 16
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Dys-homeostasis of copper metabolism and oxidative stress are major hallmarks in the brains of Alzheimer patients. Therefore, metal bioavailability and mechanisms of copper ion homeostasis throughout the body are crucial and potential targets for therapeutic agents. Many of the medications used or suggested, respectively, at present time, may either be toxic, reveal a lack of specificity or have unknown mechanisms of action in vivo. Metal chaperones from medicinal plants are proposed as medications that are relatively free from these disadvantages. Furthermore, these agents are a promising class of molecules for studies aimed at developing innovative and etiological treatments for protein-misfolding diseases, especially Alzheimer's disease.
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Copper: chemistry
650 _ 2 |2 MeSH
|a Copper: metabolism
650 _ 2 |2 MeSH
|a Dementia: drug therapy
650 _ 2 |2 MeSH
|a Homeostasis
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Molecular Chaperones: chemistry
650 _ 2 |2 MeSH
|a Molecular Chaperones: therapeutic use
650 _ 2 |2 MeSH
|a Oxidative Stress
650 _ 2 |2 MeSH
|a Plants: chemistry
650 _ 7 |0 0
|2 NLM Chemicals
|a Molecular Chaperones
650 _ 7 |0 7440-50-8
|2 NLM Chemicals
|a Copper
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a Metal chaperones
653 2 0 |2 Author
|a Alzheimer's disease
653 2 0 |2 Author
|a biochemical impact
653 2 0 |2 Author
|a SOD-1
653 2 0 |2 Author
|a CCS
653 2 0 |2 Author
|a A beta
700 1 _ |a Garfin, D.E.
|b 1
|0 P:(DE-HGF)0
700 1 _ |a Horst, J.
|b 2
|0 P:(DE-HGF)0
700 1 _ |a Nagel, K. A.
|b 3
|u FZJ
|0 P:(DE-Juel1)129373
773 _ _ |a 10.1080/13506120902879392
|g Vol. 16, p. 81 - 83
|p 81 - 83
|q 16<81 - 83
|0 PERI:(DE-600)2141924-3
|t Amyloid
|v 16
|y 2009
|x 1350-6129
856 7 _ |u http://dx.doi.org/10.1080/13506120902879392
856 4 _ |u https://juser.fz-juelich.de/record/3433/files/FZJ-3433.pdf
|z Published final document.
|y Restricted
909 C O |o oai:juser.fz-juelich.de:3433
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913 1 _ |k P24
|v Terrestrische Umwelt
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914 1 _ |y 2009
915 _ _ |a Peer review unknown
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981 _ _ |a I:(DE-Juel1)ICG-3-20090406


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