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000034923 0247_ $$2DOI$$a10.1021/bp0257473
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000034923 084__ $$2WoS$$aBiotechnology & Applied Microbiology
000034923 084__ $$2WoS$$aFood Science & Technology
000034923 1001_ $$0P:(DE-Juel1)VDB1625$$aTakors, R.$$b0$$uFZJ
000034923 245__ $$aModel-based analysis and optimization of an ISPR approach using reactive extraction for pilot scale L-Phenylalanine production
000034923 260__ $$aMalden, MA$$bWiley$$c2004
000034923 300__ $$a57 - 64
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000034923 440_0 $$0904$$aBiotechnology Progress$$v20$$x8756-7938$$y1
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000034923 520__ $$aBased on experimental data from fermentation runs, as well as from L-phenylalanine (l-Phe) separation studies, a simple model is presented that describes the total ISPR approach for on-line L-Phe separation. While fermentation process modeling via a macrokinetic model revealed an L-Phe inhibition constant of 20 +/- 1.35 g/L using recombinant E. coli cells, the reactive-extraction process modeling identified the L-Phe cation diffusion in the aqueous donor film and the transport of the lowly soluble carrier/L-Phe complex in the aqueous acceptor film as the most dominant transfer steps. The corresponding mass transfer coefficients were estimated as k(PheD) = 128 x 10(-7) cm/s (extraction) and k(CPheA) = 178 x 10(-5) cm/s (back-extraction). Simulation studies were performed for the total ISPR approach, which gave hints for strategies of further process optimization.
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000034923 650_2 $$2MeSH$$aAlgorithms
000034923 650_2 $$2MeSH$$aBioreactors: microbiology
000034923 650_2 $$2MeSH$$aComputer Simulation
000034923 650_2 $$2MeSH$$aEscherichia coli: growth & development
000034923 650_2 $$2MeSH$$aEscherichia coli: metabolism
000034923 650_2 $$2MeSH$$aFractional Precipitation
000034923 650_2 $$2MeSH$$aIndustrial Microbiology: methods
000034923 650_2 $$2MeSH$$aKinetics
000034923 650_2 $$2MeSH$$aModels, Biological
000034923 650_2 $$2MeSH$$aModels, Chemical
000034923 650_2 $$2MeSH$$aPhenylalanine: biosynthesis
000034923 650_2 $$2MeSH$$aPhenylalanine: chemistry
000034923 650_2 $$2MeSH$$aPhenylalanine: isolation & purification
000034923 650_2 $$2MeSH$$aPilot Projects
000034923 650_2 $$2MeSH$$aQuality Control
000034923 650_2 $$2MeSH$$aUltrafiltration: methods
000034923 650_7 $$063-91-2$$2NLM Chemicals$$aPhenylalanine
000034923 650_7 $$2WoSType$$aJ
000034923 773__ $$0PERI:(DE-600)2003526-3$$a10.1021/bp0257473$$gVol. 20, p. 57 - 64$$p57 - 64$$q20<57 - 64$$tBiotechnology progress$$v20$$x8756-7938$$y2004
000034923 8567_ $$uhttp://hdl.handle.net/2128/2440$$uhttp://dx.doi.org/10.1021/bp0257473
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000034923 9141_ $$y2004
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