Home > Publications database > Model-based analysis and optimization of an ISPR approach using reactive extraction for pilot scale L-Phenylalanine production > print

001     34923
005     20200423203648.0
024 7 _ |a pmid:14763824
|2 pmid
024 7 _ |a 10.1021/bp0257473
|2 DOI
024 7 _ |a WOS:000188861300008
|2 WOS
024 7 _ |a 2128/2440
|2 Handle
024 7 _ |a altmetric:21811033
|2 altmetric
037 _ _ |a PreJuSER-34923
041 _ _ |a eng
082 _ _ |a 570
084 _ _ |2 WoS
|a Biotechnology & Applied Microbiology
084 _ _ |2 WoS
|a Food Science & Technology
100 1 _ |a Takors, R.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB1625
245 _ _ |a Model-based analysis and optimization of an ISPR approach using reactive extraction for pilot scale L-Phenylalanine production
260 _ _ |a Malden, MA
|b Wiley
|c 2004
300 _ _ |a 57 - 64
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Biotechnology Progress
|x 8756-7938
|0 904
|y 1
|v 20
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Based on experimental data from fermentation runs, as well as from L-phenylalanine (l-Phe) separation studies, a simple model is presented that describes the total ISPR approach for on-line L-Phe separation. While fermentation process modeling via a macrokinetic model revealed an L-Phe inhibition constant of 20 +/- 1.35 g/L using recombinant E. coli cells, the reactive-extraction process modeling identified the L-Phe cation diffusion in the aqueous donor film and the transport of the lowly soluble carrier/L-Phe complex in the aqueous acceptor film as the most dominant transfer steps. The corresponding mass transfer coefficients were estimated as k(PheD) = 128 x 10(-7) cm/s (extraction) and k(CPheA) = 178 x 10(-5) cm/s (back-extraction). Simulation studies were performed for the total ISPR approach, which gave hints for strategies of further process optimization.
536 _ _ |a Biotechnologie
|c L02
|2 G:(DE-HGF)
|0 G:(DE-Juel1)FUEK256
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Algorithms
650 _ 2 |2 MeSH
|a Bioreactors: microbiology
650 _ 2 |2 MeSH
|a Computer Simulation
650 _ 2 |2 MeSH
|a Escherichia coli: growth & development
650 _ 2 |2 MeSH
|a Escherichia coli: metabolism
650 _ 2 |2 MeSH
|a Fractional Precipitation
650 _ 2 |2 MeSH
|a Industrial Microbiology: methods
650 _ 2 |2 MeSH
|a Kinetics
650 _ 2 |2 MeSH
|a Models, Biological
650 _ 2 |2 MeSH
|a Models, Chemical
650 _ 2 |2 MeSH
|a Phenylalanine: biosynthesis
650 _ 2 |2 MeSH
|a Phenylalanine: chemistry
650 _ 2 |2 MeSH
|a Phenylalanine: isolation & purification
650 _ 2 |2 MeSH
|a Pilot Projects
650 _ 2 |2 MeSH
|a Quality Control
650 _ 2 |2 MeSH
|a Ultrafiltration: methods
650 _ 7 |0 63-91-2
|2 NLM Chemicals
|a Phenylalanine
650 _ 7 |a J
|2 WoSType
773 _ _ |a 10.1021/bp0257473
|g Vol. 20, p. 57 - 64
|p 57 - 64
|q 20<57 - 64
|0 PERI:(DE-600)2003526-3
|t Biotechnology progress
|v 20
|y 2004
|x 8756-7938
856 7 _ |u http://dx.doi.org/10.1021/bp0257473
|u http://hdl.handle.net/2128/2440
856 4 _ |u https://juser.fz-juelich.de/record/34923/files/41107.pdf
|y OpenAccess
856 4 _ |u https://juser.fz-juelich.de/record/34923/files/41107.jpg?subformat=icon-1440
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909 C O |o oai:juser.fz-juelich.de:34923
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913 1 _ |k L02
|v Biotechnologie
|l Biotechnologie
|b Leben
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914 1 _ |y 2004
915 _ _ |0 StatID:(DE-HGF)0010
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970 _ _ |a VDB:(DE-Juel1)41107
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980 _ _ |a FullTexts
980 1 _ |a FullTexts
981 _ _ |a I:(DE-Juel1)IBG-1-20101118

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