TY  - JOUR
AU  - Gibbon, P.
AU  - Masek, M.
AU  - Teubner, U.
AU  - Lu, W.
AU  - Nicoul, M.
AU  - Shymanovich, A.
AU  - Tarasevitch, A.
AU  - Zhou, P.
AU  - Sokolowski-Tinten, K.
AU  - von der Linde, D.
TI  - Modelling and optimisation of femtosecond laser-produced K-alpha sources
JO  - Applied physics / A
VL  - 96
SN  - 0947-8396
CY  - Berlin
PB  - Springer
M1  - PreJuSER-3496
SP  - 23 - 31
PY  - 2009
N1  - This work was supported by the Deutsche Forschungsgemeinschaft (DFG grant-nos. GI 300/3-1, TE 190/6-1 and So 408/6-3) and the FLASH network.
AB  - The most reliable prognostic factor in colon cancer is the TNM classification. The objective of this study was to assess and compare the prognostic role of tumor-infiltrating lymphocytes (TILs) in stage II colon cancer.Immunohistochemistry was used to assess the density of TILs that were positive for cluster of differentiation 3 (CD3) (T-cell coreceptor), CD45 isoform RO (CD45RO) (protein tyrosine phosphatase), nuclear transcription factor forkhead box P3 (FOXP3), and CD25 (a type I transmembrane protein) according to tumor site (intraepithelial and stromal) in samples from 87 patients who had stage II colon cancer. These variables were evaluated for their association with histopathologic features along with overall survival (OS) and disease-free survival (DFS).Intraepithelial CD3-posititve (CD3+), CD45RO+, CD25+, and FOXP3+ TILs were associated significantly with better DFS (P = .049, P = .009, P = .013, and P = .001, respectively). The estimated 5-year OS rates for patients who had high-density CD45RO+ and FOXP3+ expression was 100% for both compared with 79.2% and 78.8% for patients who had low-density CD45RO+ and FOXP3+ expression (P = .017 and P = .040, respectively). A significant prognostic factor for both OS and DFS was high-density stromal CD45RO+ lymphocytic infiltration (OS: P = .031; relative risk [RR], 0.134; 95% confidence interval [CI], 0.015-1.164; DFS: P = .013; RR, 0.198; 95% CI, 0.055-0.710); whereas intraepithelial FOXP3+ expression was an independent prognostic factor for DFS (P = .032; RR, 0.108; 95% CI, 0.014-0.821).FOXP3+ and CD45RO+ TILs demonstrated independent prognostic significance for survival in the current investigation. These results may help to improve the prognostication of early stage colon cancer. Cancer 2010.
KW  - Adult
KW  - Aged
KW  - Colonic Neoplasms: immunology
KW  - Colonic Neoplasms: pathology
KW  - Disease-Free Survival
KW  - Female
KW  - Humans
KW  - Immunohistochemistry
KW  - Lymphocytes, Tumor-Infiltrating: immunology
KW  - Male
KW  - Middle Aged
KW  - Neoplasm Invasiveness
KW  - Prognosis
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:20665489
UR  - <Go to ISI:>//WOS:000266372100005
DO  - DOI:10.1007/s00339-009-5188-0
UR  - https://juser.fz-juelich.de/record/3496
ER  -