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@ARTICLE{Gibbon:3496,
      author       = {Gibbon, P. and Masek, M. and Teubner, U. and Lu, W. and
                      Nicoul, M. and Shymanovich, A. and Tarasevitch, A. and Zhou,
                      P. and Sokolowski-Tinten, K. and von der Linde, D.},
      title        = {{M}odelling and optimisation of femtosecond laser-produced
                      {K}-alpha sources},
      journal      = {Applied physics / A},
      volume       = {96},
      issn         = {0947-8396},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {PreJuSER-3496},
      pages        = {23 - 31},
      year         = {2009},
      note         = {This work was supported by the Deutsche
                      Forschungsgemeinschaft (DFG grant-nos. GI 300/3-1, TE
                      190/6-1 and So 408/6-3) and the FLASH network.},
      abstract     = {The most reliable prognostic factor in colon cancer is the
                      TNM classification. The objective of this study was to
                      assess and compare the prognostic role of tumor-infiltrating
                      lymphocytes (TILs) in stage II colon
                      cancer.Immunohistochemistry was used to assess the density
                      of TILs that were positive for cluster of differentiation 3
                      (CD3) (T-cell coreceptor), CD45 isoform RO (CD45RO) (protein
                      tyrosine phosphatase), nuclear transcription factor forkhead
                      box P3 (FOXP3), and CD25 (a type I transmembrane protein)
                      according to tumor site (intraepithelial and stromal) in
                      samples from 87 patients who had stage II colon cancer.
                      These variables were evaluated for their association with
                      histopathologic features along with overall survival (OS)
                      and disease-free survival (DFS).Intraepithelial
                      CD3-posititve (CD3+), CD45RO+, CD25+, and FOXP3+ TILs were
                      associated significantly with better DFS (P = .049, P =
                      .009, P = .013, and P = .001, respectively). The estimated
                      5-year OS rates for patients who had high-density CD45RO+
                      and FOXP3+ expression was $100\%$ for both compared with
                      $79.2\%$ and $78.8\%$ for patients who had low-density
                      CD45RO+ and FOXP3+ expression (P = .017 and P = .040,
                      respectively). A significant prognostic factor for both OS
                      and DFS was high-density stromal CD45RO+ lymphocytic
                      infiltration (OS: P = .031; relative risk [RR], 0.134;
                      $95\%$ confidence interval [CI], 0.015-1.164; DFS: P = .013;
                      RR, 0.198; $95\%$ CI, 0.055-0.710); whereas intraepithelial
                      FOXP3+ expression was an independent prognostic factor for
                      DFS (P = .032; RR, 0.108; $95\%$ CI, 0.014-0.821).FOXP3+ and
                      CD45RO+ TILs demonstrated independent prognostic
                      significance for survival in the current investigation.
                      These results may help to improve the prognostication of
                      early stage colon cancer. Cancer 2010.},
      keywords     = {Adult / Aged / Colonic Neoplasms: immunology / Colonic
                      Neoplasms: pathology / Disease-Free Survival / Female /
                      Humans / Immunohistochemistry / Lymphocytes,
                      Tumor-Infiltrating: immunology / Male / Middle Aged /
                      Neoplasm Invasiveness / Prognosis / J (WoSType)},
      cin          = {JSC},
      ddc          = {530},
      cid          = {I:(DE-Juel1)JSC-20090406},
      pnm          = {Scientific Computing},
      pid          = {G:(DE-Juel1)FUEK411},
      shelfmark    = {Materials Science, Multidisciplinary / Physics, Applied},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20665489},
      UT           = {WOS:000266372100005},
      doi          = {10.1007/s00339-009-5188-0},
      url          = {https://juser.fz-juelich.de/record/3496},
}