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000035073 0247_ $$2pmid$$apmid:15110934
000035073 0247_ $$2DOI$$a10.1016/j.bpc.2003.12.010
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000035073 084__ $$2WoS$$aBiochemistry & Molecular Biology
000035073 084__ $$2WoS$$aBiophysics
000035073 084__ $$2WoS$$aChemistry, Physical
000035073 1001_ $$0P:(DE-HGF)0$$aUhrikova, D.$$b0
000035073 245__ $$aInfluence of local anesthetics on the phophatidylcholine model membrane: small-angle synchrotron X-ray diffraction and neutron scattering study
000035073 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2004
000035073 300__ $$a361 - 373
000035073 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000035073 440_0 $$09184$$aBiophysical Chemistry$$v109$$x0301-4622
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000035073 520__ $$aThe phase preferences of egg yolk phosphatidylcholine (EYPC) have been examined in the presence of tertiary amine anesthetics [2-(propyloxy)phenyl]-2-(1-piperidinyl)ethyl ester of carbamic acid (C3A) and [2-(heptyloxy)phenyl]-2-(1-piperidinyl)ethyl ester of carbamic acid (C7A, heptacaine). Using the synchrotron small-angle X-ray diffraction (SAXD), it is shown that the C3A anesthetic induces the cubic and hexagonal (H(I)) phases at 2 > or = C3A:EYPC > 0.5 and H2O:EYPC < or = 40 molar ratios. In contrast, longer alkyloxy chain homolog C7A has no effect on the bilayer arrangement of EYPC at C7A:EYPC < = 1 molar ratios as observed by SAXD in C7A + EYPC mixtures hydrated at H2O:EYPC < = 40 molar ratios, as well as in sonicated C7A + EYPC mixtures hydrated in excess water as proved by the small-angle neutron scattering (SANS). The bilayer thickness d(L) decreases and the bilayer C7A surface area SC7A increases with the increase of C7A:EYPC molar ratio. It is suggested that the ability of tertiary amine local anesthetics to influence the dL and SC7A values and EYPC polymorphism is caused by their effective molecular shape and by charge. The possibility that anesthetic molecules may exert some of their biological effects by virtue of these properties is discussed.
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000035073 650_2 $$2MeSH$$aAmines: chemistry
000035073 650_2 $$2MeSH$$aAmines: pharmacology
000035073 650_2 $$2MeSH$$aAnesthetics, Local: chemistry
000035073 650_2 $$2MeSH$$aAnesthetics, Local: pharmacology
000035073 650_2 $$2MeSH$$aEgg Yolk: metabolism
000035073 650_2 $$2MeSH$$aLipid Bilayers: chemistry
000035073 650_2 $$2MeSH$$aMembranes: drug effects
000035073 650_2 $$2MeSH$$aModels, Biological
000035073 650_2 $$2MeSH$$aNeutrons
000035073 650_2 $$2MeSH$$aPhosphatidylcholines: chemistry
000035073 650_2 $$2MeSH$$aPolymorphism, Genetic
000035073 650_2 $$2MeSH$$aScattering, Radiation
000035073 650_2 $$2MeSH$$aStructure-Activity Relationship
000035073 650_2 $$2MeSH$$aSynchrotrons
000035073 650_2 $$2MeSH$$aX-Ray Diffraction: methods
000035073 650_7 $$00$$2NLM Chemicals$$aAmines
000035073 650_7 $$00$$2NLM Chemicals$$aAnesthetics, Local
000035073 650_7 $$00$$2NLM Chemicals$$aLipid Bilayers
000035073 650_7 $$00$$2NLM Chemicals$$aPhosphatidylcholines
000035073 650_7 $$2WoSType$$aJ
000035073 65320 $$2Author$$alipid bilayer
000035073 65320 $$2Author$$alocal anesthetic
000035073 65320 $$2Author$$a[2-(alkyloxy)phenyl]-2-(1-piperidinyl)ethyl esters of carbamic acid
000035073 65320 $$2Author$$aphosphatidylcholine
000035073 65320 $$2Author$$aX-ray diffraction
000035073 65320 $$2Author$$aneutron scattering
000035073 7001_ $$0P:(DE-HGF)0$$aRapp, G.$$b1
000035073 7001_ $$0P:(DE-HGF)0$$aYaradaikin, S.$$b2
000035073 7001_ $$0P:(DE-Juel1)VDB32237$$aGordeliy, I. L.$$b3$$uFZJ
000035073 7001_ $$0P:(DE-HGF)0$$aBalgavy, P.$$b4
000035073 773__ $$0PERI:(DE-600)1496385-1$$a10.1016/j.bpc.2003.12.010$$gVol. 109, p. 361 - 373$$p361 - 373$$q109<361 - 373$$tBiophysical chemistry$$v109$$x0301-4622$$y2004
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000035073 9201_ $$0I:(DE-Juel1)VDB58$$d31.12.2006$$gIBI$$kIBI-2$$lBiologische Strukturforschung$$x0
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