% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Uhrikova:35073,
      author       = {Uhrikova, D. and Rapp, G. and Yaradaikin, S. and Gordeliy,
                      I. L. and Balgavy, P.},
      title        = {{I}nfluence of local anesthetics on the phophatidylcholine
                      model membrane: small-angle synchrotron {X}-ray diffraction
                      and neutron scattering study},
      journal      = {Biophysical chemistry},
      volume       = {109},
      issn         = {0301-4622},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-35073},
      pages        = {361 - 373},
      year         = {2004},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The phase preferences of egg yolk phosphatidylcholine
                      (EYPC) have been examined in the presence of tertiary amine
                      anesthetics [2-(propyloxy)phenyl]-2-(1-piperidinyl)ethyl
                      ester of carbamic acid (C3A) and
                      [2-(heptyloxy)phenyl]-2-(1-piperidinyl)ethyl ester of
                      carbamic acid (C7A, heptacaine). Using the synchrotron
                      small-angle X-ray diffraction (SAXD), it is shown that the
                      C3A anesthetic induces the cubic and hexagonal (H(I)) phases
                      at 2 > or = C3A:EYPC > 0.5 and H2O:EYPC < or = 40 molar
                      ratios. In contrast, longer alkyloxy chain homolog C7A has
                      no effect on the bilayer arrangement of EYPC at C7A:EYPC < =
                      1 molar ratios as observed by SAXD in C7A + EYPC mixtures
                      hydrated at H2O:EYPC < = 40 molar ratios, as well as in
                      sonicated C7A + EYPC mixtures hydrated in excess water as
                      proved by the small-angle neutron scattering (SANS). The
                      bilayer thickness d(L) decreases and the bilayer C7A surface
                      area SC7A increases with the increase of C7A:EYPC molar
                      ratio. It is suggested that the ability of tertiary amine
                      local anesthetics to influence the dL and SC7A values and
                      EYPC polymorphism is caused by their effective molecular
                      shape and by charge. The possibility that anesthetic
                      molecules may exert some of their biological effects by
                      virtue of these properties is discussed.},
      keywords     = {Amines: chemistry / Amines: pharmacology / Anesthetics,
                      Local: chemistry / Anesthetics, Local: pharmacology / Egg
                      Yolk: metabolism / Lipid Bilayers: chemistry / Membranes:
                      drug effects / Models, Biological / Neutrons /
                      Phosphatidylcholines: chemistry / Polymorphism, Genetic /
                      Scattering, Radiation / Structure-Activity Relationship /
                      Synchrotrons / X-Ray Diffraction: methods / Amines (NLM
                      Chemicals) / Anesthetics, Local (NLM Chemicals) / Lipid
                      Bilayers (NLM Chemicals) / Phosphatidylcholines (NLM
                      Chemicals) / J (WoSType)},
      cin          = {IBI-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)VDB58},
      pnm          = {Neurowissenschaften},
      pid          = {G:(DE-Juel1)FUEK255},
      shelfmark    = {Biochemistry $\&$ Molecular Biology / Biophysics /
                      Chemistry, Physical},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:15110934},
      UT           = {WOS:000221368900004},
      doi          = {10.1016/j.bpc.2003.12.010},
      url          = {https://juser.fz-juelich.de/record/35073},
}