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000003639 0247_ $$2DOI$$a10.1016/j.brainres.2008.12.056
000003639 0247_ $$2WOS$$aWOS:000264536100006
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000003639 084__ $$2WoS$$aNeurosciences
000003639 1001_ $$0P:(DE-Juel1)131679$$aElmenhorst, D.$$b0$$uFZJ
000003639 245__ $$aSleep deprivation increases A1 adenosine receptor density in the rat brain.
000003639 260__ $$aAmsterdam$$bElsevier$$c2009
000003639 300__ $$a53 - 58
000003639 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000003639 440_0 $$0943$$aBrain Research$$v1258$$x0006-8993
000003639 500__ $$aSabine Wilms, Markus Cremer and Ramkumar Karthikeyan are gratefully acknowledged for excellent technical assistance and Marcus Holschbach for providing Tritium labeled CPFPX.This work was supported by the Department of Veterans Affairs Medical Research Service Award to RB, the National Institute of Mental Health (NIMH39683) to RWM, the Heinrich Hertz Foundation of the Ministry of Science and Technology, North-Rhine Westfalia, Germany to DE and the German Federal Ministry of Education and Research (Brain Imaging Center West, to DE and AB; and Biopharma Initiative-NeuroAllianz, to AB).
000003639 520__ $$aAdenosine, increasing after sleep deprivation and acting via the A(1) adenosine receptor (A(1)AR), is likely a key factor in the homeostatic control of sleep. This study examines the impact of sleep deprivation on A(1)AR density in different parts of the rat brain with [(3)H]CPFPX autoradiography. Binding of [(3)H]CPFPX was significantly increased in parietal cortex (PAR) (7%), thalamus (11%) and caudate-putamen (9%) after 24 h of sleep deprivation compared to a control group with an undisturbed circadian sleep-wake rhythm. Sleep deprivation of 12 h changed receptor density regionally between -5% and +9% (motor cortex (M1), statistically significant) compared to the circadian control group. These results suggest cerebral A(1)ARs are involved in effects of sleep deprivation and the regulation of sleep. The increase of A(1)AR density could serve the purpose of not only maintaining the responsiveness to increased adenosine levels but also amplifying the effect of sleep deprivation and is in line with a sleep-induced homoeostatic reorganization at the synaptic level.
000003639 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
000003639 588__ $$aDataset connected to Web of Science, Pubmed
000003639 65320 $$2Author$$aAdenosine A(1) receptor
000003639 65320 $$2Author$$aReceptor autoradiography
000003639 65320 $$2Author$$a[3H]CPFPX
000003639 65320 $$2Author$$aSleep deprivation
000003639 65320 $$2Author$$aSleep homeostasis
000003639 65320 $$2Author$$aRat
000003639 650_2 $$2MeSH$$aAdenosine A1 Receptor Antagonists
000003639 650_2 $$2MeSH$$aAnalysis of Variance
000003639 650_2 $$2MeSH$$aAnimals
000003639 650_2 $$2MeSH$$aAutoradiography
000003639 650_2 $$2MeSH$$aBrain: metabolism
000003639 650_2 $$2MeSH$$aCircadian Rhythm
000003639 650_2 $$2MeSH$$aMale
000003639 650_2 $$2MeSH$$aRats
000003639 650_2 $$2MeSH$$aRats, Sprague-Dawley
000003639 650_2 $$2MeSH$$aReceptor, Adenosine A1: metabolism
000003639 650_2 $$2MeSH$$aSleep: physiology
000003639 650_2 $$2MeSH$$aSleep Deprivation: metabolism
000003639 650_2 $$2MeSH$$aTritium
000003639 650_2 $$2MeSH$$aXanthines: metabolism
000003639 650_7 $$00$$2NLM Chemicals$$a8-cyclopenta-3-(3-fluoropropyl)-1-propylxanthine
000003639 650_7 $$00$$2NLM Chemicals$$aAdenosine A1 Receptor Antagonists
000003639 650_7 $$00$$2NLM Chemicals$$aReceptor, Adenosine A1
000003639 650_7 $$00$$2NLM Chemicals$$aXanthines
000003639 650_7 $$010028-17-8$$2NLM Chemicals$$aTritium
000003639 650_7 $$2WoSType$$aJ
000003639 7001_ $$0P:(DE-HGF)0$$aBasheer, R.$$b1
000003639 7001_ $$0P:(DE-HGF)0$$aMcCarley, R.W.$$b2
000003639 7001_ $$0P:(DE-Juel1)131672$$aBauer, A.$$b3$$uFZJ
000003639 773__ $$0PERI:(DE-600)1462674-3$$a10.1016/j.brainres.2008.12.056$$gVol. 1258, p. 53 - 58$$p53 - 58$$q1258<53 - 58$$tBrain research$$v1258$$x0006-8993$$y2009
000003639 8567_ $$uhttp://dx.doi.org/10.1016/j.brainres.2008.12.056
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