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@ARTICLE{Elmenhorst:3639,
      author       = {Elmenhorst, D. and Basheer, R. and McCarley, R.W. and
                      Bauer, A.},
      title        = {{S}leep deprivation increases {A}1 adenosine receptor
                      density in the rat brain.},
      journal      = {Brain research},
      volume       = {1258},
      issn         = {0006-8993},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {PreJuSER-3639},
      pages        = {53 - 58},
      year         = {2009},
      note         = {Sabine Wilms, Markus Cremer and Ramkumar Karthikeyan are
                      gratefully acknowledged for excellent technical assistance
                      and Marcus Holschbach for providing Tritium labeled
                      CPFPX.This work was supported by the Department of Veterans
                      Affairs Medical Research Service Award to RB, the National
                      Institute of Mental Health (NIMH39683) to RWM, the Heinrich
                      Hertz Foundation of the Ministry of Science and Technology,
                      North-Rhine Westfalia, Germany to DE and the German Federal
                      Ministry of Education and Research (Brain Imaging Center
                      West, to DE and AB; and Biopharma Initiative-NeuroAllianz,
                      to AB).},
      abstract     = {Adenosine, increasing after sleep deprivation and acting
                      via the A(1) adenosine receptor (A(1)AR), is likely a key
                      factor in the homeostatic control of sleep. This study
                      examines the impact of sleep deprivation on A(1)AR density
                      in different parts of the rat brain with [(3)H]CPFPX
                      autoradiography. Binding of [(3)H]CPFPX was significantly
                      increased in parietal cortex (PAR) $(7\%),$ thalamus
                      $(11\%)$ and caudate-putamen $(9\%)$ after 24 h of sleep
                      deprivation compared to a control group with an undisturbed
                      circadian sleep-wake rhythm. Sleep deprivation of 12 h
                      changed receptor density regionally between $-5\%$ and
                      $+9\%$ (motor cortex (M1), statistically significant)
                      compared to the circadian control group. These results
                      suggest cerebral A(1)ARs are involved in effects of sleep
                      deprivation and the regulation of sleep. The increase of
                      A(1)AR density could serve the purpose of not only
                      maintaining the responsiveness to increased adenosine levels
                      but also amplifying the effect of sleep deprivation and is
                      in line with a sleep-induced homoeostatic reorganization at
                      the synaptic level.},
      keywords     = {Adenosine A1 Receptor Antagonists / Analysis of Variance /
                      Animals / Autoradiography / Brain: metabolism / Circadian
                      Rhythm / Male / Rats / Rats, Sprague-Dawley / Receptor,
                      Adenosine A1: metabolism / Sleep: physiology / Sleep
                      Deprivation: metabolism / Tritium / Xanthines: metabolism /
                      8-cyclopenta-3-(3-fluoropropyl)-1-propylxanthine (NLM
                      Chemicals) / Adenosine A1 Receptor Antagonists (NLM
                      Chemicals) / Receptor, Adenosine A1 (NLM Chemicals) /
                      Xanthines (NLM Chemicals) / Tritium (NLM Chemicals) / J
                      (WoSType)},
      cin          = {INM-2},
      ddc          = {150},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19146833},
      UT           = {WOS:000264536100006},
      doi          = {10.1016/j.brainres.2008.12.056},
      url          = {https://juser.fz-juelich.de/record/3639},
}