TY  - JOUR
AU  - Amor, N.
AU  - Zänker, P.P.
AU  - Blümler, P.
AU  - Meise, F.
AU  - Schreiber, W.G.
AU  - Scholz, A.
AU  - Schmiedeskamp, J.
AU  - Spiess, H.W.
AU  - Münnemann, K.
TI  - Magnetic resonance imaging of dissolved hyperpolarized 129Xe using a membrane-based continuous flow system
JO  - Journal of magnetic resonance imaging
VL  - 201
SN  - 1053-1807
CY  - New York, NY
PB  - Wiley-Liss
M1  - PreJuSER-3689
SP  - 93 - 99
PY  - 2009
N1  - We thank S. Appelt and W. Hosing (FZ Julich) for the development of the xenon polarizer and H.-D. Lemke (Membrana GrnbH) for the oxygenator fiber membranes. This work was supported by the Kompetenznetz Asthma/COPD (competence network for Asthma/COPD) funded by the Federal Ministry of Education and Research (FKZ01 GI 0868-0872) and the MAIFOR program of the Johannes Gutenberg University.
AB  - A technique for continuous production of solutions containing hyperpolarized (129)Xe is explored for MRI applications. The method is based on hollow fiber membranes which inhibit the formation of foams and bubbles. A systematic analysis of various carrier agents for hyperpolarized (129)Xe has been carried out, which are applicable as contrast agents for in vivo MRI. The image quality of different hyperpolarized Xe solutions is compared and MRI results obtained in a clinical as well as in a nonclinical MRI setting are provided. Moreover, we demonstrate the application of (129)Xe contrast agents produced with our dissolution method for lung MRI by imaging hyperpolarized (129)Xe that has been both dissolved in and outgassed from a carrier liquid in a lung phantom, illustrating its potential for the measurement of lung perfusion and ventilation.
KW  - Biocompatible Materials
KW  - Image Processing, Computer-Assisted
KW  - Lung: anatomy & histology
KW  - Lung: chemistry
KW  - Lung: physiology
KW  - Magnetic Resonance Imaging: methods
KW  - Membranes, Artificial
KW  - Phantoms, Imaging
KW  - Pulmonary Circulation: physiology
KW  - Respiratory Mechanics
KW  - Solutions
KW  - Xenon Isotopes: chemistry
KW  - Biocompatible Materials (NLM Chemicals)
KW  - Membranes, Artificial (NLM Chemicals)
KW  - Solutions (NLM Chemicals)
KW  - Xenon Isotopes (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:19729327
UR  - <Go to ISI:>//WOS:000271071400013
DO  - DOI:10.1016/j.jmr.2009.08.004
UR  - https://juser.fz-juelich.de/record/3689
ER  -