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@ARTICLE{Amor:3689,
      author       = {Amor, N. and Zänker, P.P. and Blümler, P. and Meise, F.
                      and Schreiber, W.G. and Scholz, A. and Schmiedeskamp, J. and
                      Spiess, H.W. and Münnemann, K.},
      title        = {{M}agnetic resonance imaging of dissolved hyperpolarized
                      129{X}e using a membrane-based continuous flow system},
      journal      = {Journal of magnetic resonance imaging},
      volume       = {201},
      issn         = {1053-1807},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {PreJuSER-3689},
      pages        = {93 - 99},
      year         = {2009},
      note         = {We thank S. Appelt and W. Hosing (FZ Julich) for the
                      development of the xenon polarizer and H.-D. Lemke (Membrana
                      GrnbH) for the oxygenator fiber membranes. This work was
                      supported by the Kompetenznetz Asthma/COPD (competence
                      network for Asthma/COPD) funded by the Federal Ministry of
                      Education and Research (FKZ01 GI 0868-0872) and the MAIFOR
                      program of the Johannes Gutenberg University.},
      abstract     = {A technique for continuous production of solutions
                      containing hyperpolarized (129)Xe is explored for MRI
                      applications. The method is based on hollow fiber membranes
                      which inhibit the formation of foams and bubbles. A
                      systematic analysis of various carrier agents for
                      hyperpolarized (129)Xe has been carried out, which are
                      applicable as contrast agents for in vivo MRI. The image
                      quality of different hyperpolarized Xe solutions is compared
                      and MRI results obtained in a clinical as well as in a
                      nonclinical MRI setting are provided. Moreover, we
                      demonstrate the application of (129)Xe contrast agents
                      produced with our dissolution method for lung MRI by imaging
                      hyperpolarized (129)Xe that has been both dissolved in and
                      outgassed from a carrier liquid in a lung phantom,
                      illustrating its potential for the measurement of lung
                      perfusion and ventilation.},
      keywords     = {Biocompatible Materials / Image Processing,
                      Computer-Assisted / Lung: anatomy $\&$ histology / Lung:
                      chemistry / Lung: physiology / Magnetic Resonance Imaging:
                      methods / Membranes, Artificial / Phantoms, Imaging /
                      Pulmonary Circulation: physiology / Respiratory Mechanics /
                      Solutions / Xenon Isotopes: chemistry / Biocompatible
                      Materials (NLM Chemicals) / Membranes, Artificial (NLM
                      Chemicals) / Solutions (NLM Chemicals) / Xenon Isotopes (NLM
                      Chemicals) / J (WoSType)},
      cin          = {ICG-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICG-3-20090406},
      pnm          = {Terrestrische Umwelt},
      pid          = {G:(DE-Juel1)FUEK407},
      shelfmark    = {Biochemical Research Methods / Physics, Atomic, Molecular
                      $\&$ Chemical / Spectroscopy},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19729327},
      UT           = {WOS:000271071400013},
      doi          = {10.1016/j.jmr.2009.08.004},
      url          = {https://juser.fz-juelich.de/record/3689},
}