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000003691 0247_ $$2DOI$$a10.1016/j.jpsychires.2008.10.012
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000003691 084__ $$2WoS$$aPsychiatry
000003691 1001_ $$0P:(DE-HGF)0$$aReske, M.$$b0
000003691 245__ $$aDifferential brain activation during facial emotion discrimination in first-episode schizophrenie
000003691 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2009
000003691 300__ $$a592 - 599
000003691 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000003691 440_0 $$017621$$aJournal of Psychiatric Research$$v43$$x0022-3956$$y6
000003691 500__ $$aThis study was part of the German Research Network on Schizophrenia and was funded by the German Federal Ministry for Education and Research (BMBF, grant 01 GI 9932) and the German Research Foundation (DFG, Schn 362/13-1 and 13-2). The MRI facility in Julich is supported by the German Federal Ministry for Education and Research (BMBF; grant 01 GO 0104). The funding sources had no further role in study design, data collection, analyses, interpretation, nor in writing of the report or in the decision to submit this work for publication.
000003691 520__ $$aAberrant brain activation during facial emotion discrimination has been described in chronic schizophrenia, while little is known about early stages of the illness. The aim of the current study was to investigate valence-specific brain activation of emotion discrimination in first-episode schizophrenia. These patients provide the advantage of lacking the effects of long-term medication and chronic illness course and can hence further enhance the understanding of underlying psychopathological mechanisms.Using event-related fMRI, we investigated 18 first-episode schizophrenia patients and 18 matched healthy subjects during an explicit emotion discrimination task presenting happy, sad and neutral monochromatic facial expressions. A repeated measure analysis of variance (ANOVA) with the factors Group (patients, healthy subjects), Gender and Emotion (happy, sad, neutral) was performed on behavioural and functional data.Behavioural performance did not differ between groups. Valence-independent hypoactivations in patients were observed for the anterior cingulate and orbitofrontal cortex while hyperactivations emerged in the posterior cingulate and the precuneus. Emotion-specific group differences were revealed in inferior parietal and orbitofrontal brain areas and the hippocampus.First-episode schizophrenia already affects areas involved in processing of both, emotions and primary facial information. Our study underlines the role of dysfunctional neural networks as the basis of disturbed social interactions in early schizophrenia.
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000003691 588__ $$aDataset connected to Web of Science, Pubmed
000003691 65320 $$2Author$$aSchizophrenia
000003691 65320 $$2Author$$aFirst-episode
000003691 65320 $$2Author$$aEmotion discrimination
000003691 65320 $$2Author$$aValence
000003691 65320 $$2Author$$aFace processing
000003691 65320 $$2Author$$aFMRI
000003691 650_2 $$2MeSH$$aAdolescent
000003691 650_2 $$2MeSH$$aAdult
000003691 650_2 $$2MeSH$$aAntipsychotic Agents: therapeutic use
000003691 650_2 $$2MeSH$$aBrain: drug effects
000003691 650_2 $$2MeSH$$aBrain: physiopathology
000003691 650_2 $$2MeSH$$aBrain Mapping: methods
000003691 650_2 $$2MeSH$$aCues
000003691 650_2 $$2MeSH$$aDiscrimination (Psychology)
000003691 650_2 $$2MeSH$$aEcho-Planar Imaging: methods
000003691 650_2 $$2MeSH$$aEmotions
000003691 650_2 $$2MeSH$$aFacial Expression
000003691 650_2 $$2MeSH$$aFemale
000003691 650_2 $$2MeSH$$aGermany
000003691 650_2 $$2MeSH$$aHaloperidol: therapeutic use
000003691 650_2 $$2MeSH$$aHumans
000003691 650_2 $$2MeSH$$aImaging, Three-Dimensional: methods
000003691 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000003691 650_2 $$2MeSH$$aMale
000003691 650_2 $$2MeSH$$aNerve Net: physiopathology
000003691 650_2 $$2MeSH$$aPsychiatric Status Rating Scales: statistics & numerical data
000003691 650_2 $$2MeSH$$aRisperidone: therapeutic use
000003691 650_2 $$2MeSH$$aSchizophrenia: diagnosis
000003691 650_2 $$2MeSH$$aSchizophrenia: drug therapy
000003691 650_2 $$2MeSH$$aSchizophrenia: physiopathology
000003691 650_2 $$2MeSH$$aTask Performance and Analysis
000003691 650_2 $$2MeSH$$aYoung Adult
000003691 650_7 $$00$$2NLM Chemicals$$aAntipsychotic Agents
000003691 650_7 $$0106266-06-2$$2NLM Chemicals$$aRisperidone
000003691 650_7 $$052-86-8$$2NLM Chemicals$$aHaloperidol
000003691 650_7 $$2WoSType$$aJ
000003691 7001_ $$0P:(DE-HGF)0$$aHabel, U.$$b1
000003691 7001_ $$0P:(DE-HGF)0$$aKellermann, T.$$b2
000003691 7001_ $$0P:(DE-HGF)0$$aBackes, V.$$b3
000003691 7001_ $$0P:(DE-Juel1)131794$$aShah, J. N.$$b4$$uFZJ
000003691 7001_ $$0P:(DE-HGF)0$$avon Wilmsdorff, M.$$b5
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000003691 7001_ $$0P:(DE-Juel1)VDB1968$$aSchneider, F.$$b8$$uFZJ
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