TY  - JOUR
AU  - Reske, M.
AU  - Habel, U.
AU  - Kellermann, T.
AU  - Backes, V.
AU  - Shah, J. N.
AU  - von Wilmsdorff, M.
AU  - Gaebel, W.
AU  - Zilles, K.
AU  - Schneider, F.
TI  - Differential brain activation during facial emotion discrimination in first-episode schizophrenie
JO  - Journal of psychiatric research
VL  - 43
SN  - 0022-3956
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-3691
SP  - 592 - 599
PY  - 2009
N1  - This study was part of the German Research Network on Schizophrenia and was funded by the German Federal Ministry for Education and Research (BMBF, grant 01 GI 9932) and the German Research Foundation (DFG, Schn 362/13-1 and 13-2). The MRI facility in Julich is supported by the German Federal Ministry for Education and Research (BMBF; grant 01 GO 0104). The funding sources had no further role in study design, data collection, analyses, interpretation, nor in writing of the report or in the decision to submit this work for publication.
AB  - Aberrant brain activation during facial emotion discrimination has been described in chronic schizophrenia, while little is known about early stages of the illness. The aim of the current study was to investigate valence-specific brain activation of emotion discrimination in first-episode schizophrenia. These patients provide the advantage of lacking the effects of long-term medication and chronic illness course and can hence further enhance the understanding of underlying psychopathological mechanisms.Using event-related fMRI, we investigated 18 first-episode schizophrenia patients and 18 matched healthy subjects during an explicit emotion discrimination task presenting happy, sad and neutral monochromatic facial expressions. A repeated measure analysis of variance (ANOVA) with the factors Group (patients, healthy subjects), Gender and Emotion (happy, sad, neutral) was performed on behavioural and functional data.Behavioural performance did not differ between groups. Valence-independent hypoactivations in patients were observed for the anterior cingulate and orbitofrontal cortex while hyperactivations emerged in the posterior cingulate and the precuneus. Emotion-specific group differences were revealed in inferior parietal and orbitofrontal brain areas and the hippocampus.First-episode schizophrenia already affects areas involved in processing of both, emotions and primary facial information. Our study underlines the role of dysfunctional neural networks as the basis of disturbed social interactions in early schizophrenia.
KW  - Adolescent
KW  - Adult
KW  - Antipsychotic Agents: therapeutic use
KW  - Brain: drug effects
KW  - Brain: physiopathology
KW  - Brain Mapping: methods
KW  - Cues
KW  - Discrimination (Psychology)
KW  - Echo-Planar Imaging: methods
KW  - Emotions
KW  - Facial Expression
KW  - Female
KW  - Germany
KW  - Haloperidol: therapeutic use
KW  - Humans
KW  - Imaging, Three-Dimensional: methods
KW  - Magnetic Resonance Imaging: methods
KW  - Male
KW  - Nerve Net: physiopathology
KW  - Psychiatric Status Rating Scales: statistics & numerical data
KW  - Risperidone: therapeutic use
KW  - Schizophrenia: diagnosis
KW  - Schizophrenia: drug therapy
KW  - Schizophrenia: physiopathology
KW  - Task Performance and Analysis
KW  - Young Adult
KW  - Antipsychotic Agents (NLM Chemicals)
KW  - Risperidone (NLM Chemicals)
KW  - Haloperidol (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:19056093
UR  - <Go to ISI:>//WOS:000264613200003
DO  - DOI:10.1016/j.jpsychires.2008.10.012
UR  - https://juser.fz-juelich.de/record/3691
ER  -