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@ARTICLE{Reske:3691,
      author       = {Reske, M. and Habel, U. and Kellermann, T. and Backes, V.
                      and Shah, J. N. and von Wilmsdorff, M. and Gaebel, W. and
                      Zilles, K. and Schneider, F.},
      title        = {{D}ifferential brain activation during facial emotion
                      discrimination in first-episode schizophrenie},
      journal      = {Journal of psychiatric research},
      volume       = {43},
      issn         = {0022-3956},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-3691},
      pages        = {592 - 599},
      year         = {2009},
      note         = {This study was part of the German Research Network on
                      Schizophrenia and was funded by the German Federal Ministry
                      for Education and Research (BMBF, grant 01 GI 9932) and the
                      German Research Foundation (DFG, Schn 362/13-1 and 13-2).
                      The MRI facility in Julich is supported by the German
                      Federal Ministry for Education and Research (BMBF; grant 01
                      GO 0104). The funding sources had no further role in study
                      design, data collection, analyses, interpretation, nor in
                      writing of the report or in the decision to submit this work
                      for publication.},
      abstract     = {Aberrant brain activation during facial emotion
                      discrimination has been described in chronic schizophrenia,
                      while little is known about early stages of the illness. The
                      aim of the current study was to investigate valence-specific
                      brain activation of emotion discrimination in first-episode
                      schizophrenia. These patients provide the advantage of
                      lacking the effects of long-term medication and chronic
                      illness course and can hence further enhance the
                      understanding of underlying psychopathological
                      mechanisms.Using event-related fMRI, we investigated 18
                      first-episode schizophrenia patients and 18 matched healthy
                      subjects during an explicit emotion discrimination task
                      presenting happy, sad and neutral monochromatic facial
                      expressions. A repeated measure analysis of variance (ANOVA)
                      with the factors Group (patients, healthy subjects), Gender
                      and Emotion (happy, sad, neutral) was performed on
                      behavioural and functional data.Behavioural performance did
                      not differ between groups. Valence-independent
                      hypoactivations in patients were observed for the anterior
                      cingulate and orbitofrontal cortex while hyperactivations
                      emerged in the posterior cingulate and the precuneus.
                      Emotion-specific group differences were revealed in inferior
                      parietal and orbitofrontal brain areas and the
                      hippocampus.First-episode schizophrenia already affects
                      areas involved in processing of both, emotions and primary
                      facial information. Our study underlines the role of
                      dysfunctional neural networks as the basis of disturbed
                      social interactions in early schizophrenia.},
      keywords     = {Adolescent / Adult / Antipsychotic Agents: therapeutic use
                      / Brain: drug effects / Brain: physiopathology / Brain
                      Mapping: methods / Cues / Discrimination (Psychology) /
                      Echo-Planar Imaging: methods / Emotions / Facial Expression
                      / Female / Germany / Haloperidol: therapeutic use / Humans /
                      Imaging, Three-Dimensional: methods / Magnetic Resonance
                      Imaging: methods / Male / Nerve Net: physiopathology /
                      Psychiatric Status Rating Scales: statistics $\&$ numerical
                      data / Risperidone: therapeutic use / Schizophrenia:
                      diagnosis / Schizophrenia: drug therapy / Schizophrenia:
                      physiopathology / Task Performance and Analysis / Young
                      Adult / Antipsychotic Agents (NLM Chemicals) / Risperidone
                      (NLM Chemicals) / Haloperidol (NLM Chemicals) / J (WoSType)},
      cin          = {INM-4 / INM-2 / INM-3 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-2-20090406 /
                      I:(DE-Juel1)INM-3-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Psychiatry},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19056093},
      UT           = {WOS:000264613200003},
      doi          = {10.1016/j.jpsychires.2008.10.012},
      url          = {https://juser.fz-juelich.de/record/3691},
}