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| Home > Publications database > Differential brain activation during facial emotion discrimination in first-episode schizophrenie > print |
| 001 | 3691 | ||
| 005 | 20180208220938.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:19056093 |
| 024 | 7 | _ | |2 DOI |a 10.1016/j.jpsychires.2008.10.012 |
| 024 | 7 | _ | |2 WOS |a WOS:000264613200003 |
| 037 | _ | _ | |a PreJuSER-3691 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 084 | _ | _ | |2 WoS |a Psychiatry |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Reske, M. |b 0 |
| 245 | _ | _ | |a Differential brain activation during facial emotion discrimination in first-episode schizophrenie |
| 260 | _ | _ | |a Amsterdam [u.a.] |b Elsevier Science |c 2009 |
| 300 | _ | _ | |a 592 - 599 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |0 17621 |a Journal of Psychiatric Research |v 43 |x 0022-3956 |y 6 |
| 500 | _ | _ | |a This study was part of the German Research Network on Schizophrenia and was funded by the German Federal Ministry for Education and Research (BMBF, grant 01 GI 9932) and the German Research Foundation (DFG, Schn 362/13-1 and 13-2). The MRI facility in Julich is supported by the German Federal Ministry for Education and Research (BMBF; grant 01 GO 0104). The funding sources had no further role in study design, data collection, analyses, interpretation, nor in writing of the report or in the decision to submit this work for publication. |
| 520 | _ | _ | |a Aberrant brain activation during facial emotion discrimination has been described in chronic schizophrenia, while little is known about early stages of the illness. The aim of the current study was to investigate valence-specific brain activation of emotion discrimination in first-episode schizophrenia. These patients provide the advantage of lacking the effects of long-term medication and chronic illness course and can hence further enhance the understanding of underlying psychopathological mechanisms.Using event-related fMRI, we investigated 18 first-episode schizophrenia patients and 18 matched healthy subjects during an explicit emotion discrimination task presenting happy, sad and neutral monochromatic facial expressions. A repeated measure analysis of variance (ANOVA) with the factors Group (patients, healthy subjects), Gender and Emotion (happy, sad, neutral) was performed on behavioural and functional data.Behavioural performance did not differ between groups. Valence-independent hypoactivations in patients were observed for the anterior cingulate and orbitofrontal cortex while hyperactivations emerged in the posterior cingulate and the precuneus. Emotion-specific group differences were revealed in inferior parietal and orbitofrontal brain areas and the hippocampus.First-episode schizophrenia already affects areas involved in processing of both, emotions and primary facial information. Our study underlines the role of dysfunctional neural networks as the basis of disturbed social interactions in early schizophrenia. |
| 536 | _ | _ | |0 G:(DE-Juel1)FUEK409 |2 G:(DE-HGF) |a Funktion und Dysfunktion des Nervensystems |c P33 |x 0 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Adolescent |
| 650 | _ | 2 | |2 MeSH |a Adult |
| 650 | _ | 2 | |2 MeSH |a Antipsychotic Agents: therapeutic use |
| 650 | _ | 2 | |2 MeSH |a Brain: drug effects |
| 650 | _ | 2 | |2 MeSH |a Brain: physiopathology |
| 650 | _ | 2 | |2 MeSH |a Brain Mapping: methods |
| 650 | _ | 2 | |2 MeSH |a Cues |
| 650 | _ | 2 | |2 MeSH |a Discrimination (Psychology) |
| 650 | _ | 2 | |2 MeSH |a Echo-Planar Imaging: methods |
| 650 | _ | 2 | |2 MeSH |a Emotions |
| 650 | _ | 2 | |2 MeSH |a Facial Expression |
| 650 | _ | 2 | |2 MeSH |a Female |
| 650 | _ | 2 | |2 MeSH |a Germany |
| 650 | _ | 2 | |2 MeSH |a Haloperidol: therapeutic use |
| 650 | _ | 2 | |2 MeSH |a Humans |
| 650 | _ | 2 | |2 MeSH |a Imaging, Three-Dimensional: methods |
| 650 | _ | 2 | |2 MeSH |a Magnetic Resonance Imaging: methods |
| 650 | _ | 2 | |2 MeSH |a Male |
| 650 | _ | 2 | |2 MeSH |a Nerve Net: physiopathology |
| 650 | _ | 2 | |2 MeSH |a Psychiatric Status Rating Scales: statistics & numerical data |
| 650 | _ | 2 | |2 MeSH |a Risperidone: therapeutic use |
| 650 | _ | 2 | |2 MeSH |a Schizophrenia: diagnosis |
| 650 | _ | 2 | |2 MeSH |a Schizophrenia: drug therapy |
| 650 | _ | 2 | |2 MeSH |a Schizophrenia: physiopathology |
| 650 | _ | 2 | |2 MeSH |a Task Performance and Analysis |
| 650 | _ | 2 | |2 MeSH |a Young Adult |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Antipsychotic Agents |
| 650 | _ | 7 | |0 106266-06-2 |2 NLM Chemicals |a Risperidone |
| 650 | _ | 7 | |0 52-86-8 |2 NLM Chemicals |a Haloperidol |
| 650 | _ | 7 | |2 WoSType |a J |
| 653 | 2 | 0 | |2 Author |a Schizophrenia |
| 653 | 2 | 0 | |2 Author |a First-episode |
| 653 | 2 | 0 | |2 Author |a Emotion discrimination |
| 653 | 2 | 0 | |2 Author |a Valence |
| 653 | 2 | 0 | |2 Author |a Face processing |
| 653 | 2 | 0 | |2 Author |a FMRI |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Habel, U. |b 1 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Kellermann, T. |b 2 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Backes, V. |b 3 |
| 700 | 1 | _ | |0 P:(DE-Juel1)131794 |a Shah, J. N. |b 4 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a von Wilmsdorff, M. |b 5 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Gaebel, W. |b 6 |
| 700 | 1 | _ | |0 P:(DE-Juel1)131714 |a Zilles, K. |b 7 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-Juel1)VDB1968 |a Schneider, F. |b 8 |u FZJ |
| 773 | _ | _ | |0 PERI:(DE-600)1500641-4 |a 10.1016/j.jpsychires.2008.10.012 |g Vol. 43, p. 592 - 599 |p 592 - 599 |q 43<592 - 599 |t Journal of psychiatric research |v 43 |x 0022-3956 |y 2009 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1016/j.jpsychires.2008.10.012 |
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| 914 | 1 | _ | |y 2009 |
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