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000003697 0247_ $$2DOI$$a10.1093/cercor/bhn141
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000003697 084__ $$2WoS$$aNeurosciences
000003697 1001_ $$0P:(DE-HGF)0$$aHelmstaedter, M.$$b0
000003697 245__ $$aNeuronal Correlates of Local, Lateral and Translaminar Inhibition with Reference to Cortical Columns
000003697 260__ $$aOxford$$bOxford Univ. Press$$c2009
000003697 300__ $$a926 - 937
000003697 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000003697 440_0 $$01171$$aCerebral Cortex$$v19$$x1047-3211$$y4
000003697 500__ $$aThis work was supported by the Max-Planck Society.
000003697 520__ $$aIn the neocortex, inhibition by gamma-aminobutyric acidergic (GABAergic) interneurons is essential for shaping cortical maps, which represent sensory signals. For a detailed understanding of the stream of excitation evoked, for example, by a sensory stimulus, interneurons must be identified with reference to their impact on excitatory neurons located in different laminae of the same (home) and surround columns. We analyzed the axonal projection of layer 2/3 (L2/3) interneurons with reference to geometric landmarks of cortical columns by staining neurons in acute slices of rat barrel cortex (P20-P29) and a subsequent cluster analysis using morphological parameters that described the spatial distribution of axons. The cluster analysis defined 4 main axonal projection "types" referred to as 1) "local inhibitors" (including "chandelier neurons"), 2) "lateral inhibitors," 3) "translaminar L2/3-to-L4/5 inhibitors," and 4) "translaminar L2/3-to-L1 inhibitors." The putative innervation domains established by axonal projections of the 4 types of interneurons and the dendritic domains of their target excitatory neurons were 1) L2/3 of the home column, 2) L2/3 of both the home and neighboring columns, 3) L4 and L5A of the home column, and 4) L1 and L2/3 of the home column. The quantitative analysis of the axonal projection patterns of an unselected sample of 51 interneurons located in L2/3 thus defined anatomical correlates for local, lateral, and translaminar inhibition within and between cortical columns.
000003697 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
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000003697 65320 $$2Author$$aaxon
000003697 65320 $$2Author$$abarrel cortex
000003697 65320 $$2Author$$acluster analysis
000003697 65320 $$2Author$$acortical column
000003697 65320 $$2Author$$aGABAergic interneuron
000003697 65320 $$2Author$$alateral inhibition
000003697 65320 $$2Author$$alayer 2
000003697 65320 $$2Author$$a3
000003697 650_2 $$2MeSH$$aAnimals
000003697 650_2 $$2MeSH$$aFunctional Laterality: physiology
000003697 650_2 $$2MeSH$$aNeural Inhibition: physiology
000003697 650_2 $$2MeSH$$aNeurons: cytology
000003697 650_2 $$2MeSH$$aNeurons: physiology
000003697 650_2 $$2MeSH$$aRats
000003697 650_2 $$2MeSH$$aRats, Wistar
000003697 650_2 $$2MeSH$$aSomatosensory Cortex: cytology
000003697 650_2 $$2MeSH$$aSomatosensory Cortex: physiology
000003697 650_7 $$2WoSType$$aJ
000003697 7001_ $$0P:(DE-HGF)0$$aSakmann, B.$$b1
000003697 7001_ $$0P:(DE-Juel1)131680$$aFeldmeyer, D.$$b2$$uFZJ
000003697 773__ $$0PERI:(DE-600)1483485-6$$a10.1093/cercor/bhn141$$gVol. 19, p. 926 - 937$$p926 - 937$$q19<926 - 937$$tCerebral cortex$$v19$$x1047-3211$$y2009
000003697 8567_ $$uhttp://dx.doi.org/10.1093/cercor/bhn141
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