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@ARTICLE{Helmstaedter:3698,
      author       = {Helmstaedter, M. and Sakmann, B. and Feldmeyer, D.},
      title        = {{T}he {R}elation between {D}endritic {G}eometry,
                      {E}lectrical {E}xcitability, and {A}xonal {P}rojections of
                      {L}2/3 {I}nterneurons in {R}at {B}arrel {C}ortex},
      journal      = {Cerebral cortex},
      volume       = {19},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {PreJuSER-3698},
      pages        = {938 - 950},
      year         = {2009},
      note         = {This work was supported by the Max-Planck Society.},
      abstract     = {Interneurons in layer 2/3 (L2/3) of the somatosensory
                      cortex show 4 types of axonal projection patterns with
                      reference to the laminae and borders of columns in rat
                      barrel cortex (Helmstaedter et al. 2008a). Here, we analyzed
                      the dendritic geometry and electrical excitability of these
                      interneurons. First, dendritic polarity, measured based on
                      the insertion points of primary dendrites on the soma
                      surface, yielded a continuous one-dimensional measure
                      without a clustering of dendritic polarity types. Secondly,
                      we analyzed polar and vertical distributions of dendritic
                      length. A cluster analysis allowed the definition of 7 types
                      of dendritic arborization. Thirdly, when dendritic polarity
                      was related to the intrinsic electrical excitability we
                      found that the ratio of frequency adaptation in trains of
                      action potentials (APs) evoked by current injection was
                      correlated with the number of primary dendrites. Numerical
                      simulations of spiking patterns in L2/3 interneurons
                      suggested that the number of primary dendrites could account
                      for up to $50\%$ of this correlation. Fourthly, dendritic
                      arborization was not correlated with axonal projection, and
                      axonal projection types could not be predicted by electrical
                      excitability parameters. We conclude that 1) dendritic
                      polarity is correlated to intrinsic electrical excitability,
                      and 2) the axonal projection pattern represents an
                      independent classifier of interneurons.},
      keywords     = {Animals / Axons: physiology / Cerebral Cortex: cytology /
                      Cerebral Cortex: physiology / Dendrites: physiology /
                      Excitatory Postsynaptic Potentials: physiology /
                      Interneurons: cytology / Interneurons: physiology / Membrane
                      Potentials: physiology / Neural Pathways: physiology / Rats
                      / Rats, Wistar / J (WoSType)},
      cin          = {INM-2 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:18787231},
      UT           = {WOS:000263945100018},
      doi          = {10.1093/cercor/bhn138},
      url          = {https://juser.fz-juelich.de/record/3698},
}