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000003699 0247_ $$2pmid$$apmid:18802122
000003699 0247_ $$2DOI$$a10.1093/cercor/bhn130
000003699 0247_ $$2WOS$$aWOS:000263945100019
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000003699 041__ $$aeng
000003699 082__ $$a610
000003699 084__ $$2WoS$$aNeurosciences
000003699 1001_ $$0P:(DE-HGF)0$$aHelmstaedter, M.$$b0
000003699 245__ $$aL2/3 Interneuron Groups Defined by Multiparameter Analysis of Axonal Projection, Dendritic Geometry, and Electrical Excitability
000003699 260__ $$aOxford$$bOxford Univ. Press$$c2009
000003699 300__ $$a951 - 962
000003699 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000003699 440_0 $$01171$$aCerebral Cortex$$v19$$x1047-3211$$y4
000003699 500__ $$aThis work was supported by the Max-Planck Society.
000003699 520__ $$aFor a detailed description of the circuitry of cortical columns at the level of single neurons, it is essential to define the identities of the cell types that constitute these columns. For interneurons (INs), we described 4 "types of axonal projection patterns" in layer 2/3 (L2/3) with reference to the outlines of a cortical column (Helmstaedter et al. 2008a). In addition we quantified the dendritic geometry and electrical excitability of 3 types of the L2/3 INs: "local," "lateral," and "translaminar" inhibitors (Helmstaedter et al. 2008b). Here, we used an iterated cluster analysis (iCA) that combines axonal projection patterns with dendritic geometry and electrical excitability parameters to identify "groups" of INs, from a sample of 39 cells. The iCA defined 9 groups of INs. We propose a hierarchical scheme for identifying L2/3 INs. First, L2/3 INs can be classified as 4 types of axonal projections. Second, L2/3 INs can be subclassified as 9 groups with a high within-group similarity of dendritic, axonal, and electrical parameters. This scheme of identifying L2/3 INs may help to quantitatively describe inhibitory effects on sensory stimulus representations in L2/3 of cortical columns.
000003699 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
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000003699 65320 $$2Author$$aaxons
000003699 65320 $$2Author$$abarrel cortex
000003699 65320 $$2Author$$acluster analysis
000003699 65320 $$2Author$$adendrites
000003699 65320 $$2Author$$aelectrical excitability
000003699 65320 $$2Author$$aGABAergic interneuron
000003699 65320 $$2Author$$alateral inhibition
000003699 65320 $$2Author$$alayer 2
000003699 65320 $$2Author$$a3
000003699 650_2 $$2MeSH$$aAction Potentials: physiology
000003699 650_2 $$2MeSH$$aAnimals
000003699 650_2 $$2MeSH$$aAxons: physiology
000003699 650_2 $$2MeSH$$aDendrites: physiology
000003699 650_2 $$2MeSH$$aExcitatory Postsynaptic Potentials: physiology
000003699 650_2 $$2MeSH$$aInterneurons: cytology
000003699 650_2 $$2MeSH$$aInterneurons: physiology
000003699 650_2 $$2MeSH$$aNeural Pathways: cytology
000003699 650_2 $$2MeSH$$aNeural Pathways: physiology
000003699 650_2 $$2MeSH$$aRats
000003699 650_2 $$2MeSH$$aRats, Wistar
000003699 650_2 $$2MeSH$$aSomatosensory Cortex: physiology
000003699 650_7 $$2WoSType$$aJ
000003699 7001_ $$0P:(DE-HGF)0$$aSakmann, B.$$b1
000003699 7001_ $$0P:(DE-Juel1)131680$$aFeldmeyer, D.$$b2$$uFZJ
000003699 773__ $$0PERI:(DE-600)1483485-6$$a10.1093/cercor/bhn130$$gVol. 19, p. 951 - 962$$p951 - 962$$q19<951 - 962$$tCerebral cortex$$v19$$x1047-3211$$y2009
000003699 8567_ $$uhttp://dx.doi.org/10.1093/cercor/bhn130
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