TY  - JOUR
AU  - Helmstaedter, M.
AU  - Sakmann, B.
AU  - Feldmeyer, D.
TI  - L2/3 Interneuron Groups Defined by Multiparameter Analysis of Axonal Projection, Dendritic Geometry, and Electrical Excitability
JO  - Cerebral cortex
VL  - 19
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - PreJuSER-3699
SP  - 951 - 962
PY  - 2009
N1  - This work was supported by the Max-Planck Society.
AB  - For a detailed description of the circuitry of cortical columns at the level of single neurons, it is essential to define the identities of the cell types that constitute these columns. For interneurons (INs), we described 4 "types of axonal projection patterns" in layer 2/3 (L2/3) with reference to the outlines of a cortical column (Helmstaedter et al. 2008a). In addition we quantified the dendritic geometry and electrical excitability of 3 types of the L2/3 INs: "local," "lateral," and "translaminar" inhibitors (Helmstaedter et al. 2008b). Here, we used an iterated cluster analysis (iCA) that combines axonal projection patterns with dendritic geometry and electrical excitability parameters to identify "groups" of INs, from a sample of 39 cells. The iCA defined 9 groups of INs. We propose a hierarchical scheme for identifying L2/3 INs. First, L2/3 INs can be classified as 4 types of axonal projections. Second, L2/3 INs can be subclassified as 9 groups with a high within-group similarity of dendritic, axonal, and electrical parameters. This scheme of identifying L2/3 INs may help to quantitatively describe inhibitory effects on sensory stimulus representations in L2/3 of cortical columns.
KW  - Action Potentials: physiology
KW  - Animals
KW  - Axons: physiology
KW  - Dendrites: physiology
KW  - Excitatory Postsynaptic Potentials: physiology
KW  - Interneurons: cytology
KW  - Interneurons: physiology
KW  - Neural Pathways: cytology
KW  - Neural Pathways: physiology
KW  - Rats
KW  - Rats, Wistar
KW  - Somatosensory Cortex: physiology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:18802122
UR  - <Go to ISI:>//WOS:000263945100019
DO  - DOI:10.1093/cercor/bhn130
UR  - https://juser.fz-juelich.de/record/3699
ER  -