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@ARTICLE{Smith:400,
      author       = {Smith, A. and Sengupta, K. and Goennewein, S. and Seifert,
                      U. and Sackmann, E.},
      title        = {{F}orce-induced growth of adhesion domains is controlled by
                      receptor mobility},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {105},
      issn         = {0027-8424},
      address      = {Washington, DC},
      publisher    = {Academy},
      reportid     = {PreJuSER-400},
      pages        = {6906 - 6911},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {In living cells, adhesion structures have the astonishing
                      ability to grow and strengthen under force. Despite the
                      rising evidence of the importance of this phenomenon, little
                      is known about the underlying mechanism. Here, we show that
                      force-induced adhesion-strengthening can occur purely
                      because of the thermodynamic response to the elastic
                      deformation of the membrane, even in the absence of the
                      actively regulated cytoskeleton of the cell, which was
                      hitherto deemed necessary. We impose pN-forces on two fluid
                      membranes, locally pre-adhered by RGD-integrin binding. One
                      of the binding partners is always mobile whereas the
                      mobility of the other can be switched on or off. Immediate
                      passive strengthening of adhesion structures occurs in both
                      cases. When both binding partners are mobile, strengthening
                      is aided by lateral movement of intact bonds as a transient
                      response to force-induced membrane-deformation. By extending
                      our microinterferometric technique to the suboptical regime,
                      we show that the adhesion, as well as the resistance to
                      force-induced de-adhesion, is greatly enhanced when both,
                      rather than only one, of the binding partners are mobile. We
                      formulate a theory that explains our observations by linking
                      the macroscopic shape deformation with the microscopic
                      formation of bonds, which further elucidates the importance
                      of receptor mobility. We propose this fast passive response
                      to be the first-recognition that triggers signaling events
                      leading to mechanosensing in living cells.},
      keywords     = {Biomechanics / Cell Adhesion / Elasticity / Integrins:
                      metabolism / Models, Biological / Oligopeptides: metabolism
                      / Protein Transport / Unilamellar Liposomes: metabolism /
                      Integrins (NLM Chemicals) / Oligopeptides (NLM Chemicals) /
                      Unilamellar Liposomes (NLM Chemicals) /
                      arginyl-glycyl-aspartic acid (NLM Chemicals) / J (WoSType)},
      cin          = {IBN-4},
      ddc          = {000},
      cid          = {I:(DE-Juel1)VDB802},
      pnm          = {Kondensierte Materie},
      pid          = {G:(DE-Juel1)FUEK414},
      shelfmark    = {Multidisciplinary Sciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:18463289},
      pmc          = {pmc:PMC2383988},
      UT           = {WOS:000255921200023},
      doi          = {10.1073/pnas.0801706105},
      url          = {https://juser.fz-juelich.de/record/400},
}