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000004229 0247_ $$2DOI$$a10.1073/pnas.0811484106
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000004229 041__ $$aeng
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000004229 084__ $$2WoS$$aMultidisciplinary Sciences
000004229 1001_ $$0P:(DE-Juel1)VDB69544$$aMcWhirter, J. L.$$b0$$uFZJ
000004229 245__ $$aFlow-induced clustering and alignment of vesicles and red blood cells in microcapillaries
000004229 260__ $$aWashington, DC$$bAcademy$$c2009
000004229 300__ $$a6039 - 6043
000004229 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000004229 440_0 $$05100$$aProceedings of the National Academy of Sciences of the United States of America$$v106$$x0027-8424$$y15
000004229 500__ $$aStimulating discussions with U. B. Kaupp are gratefully acknowledged. This work was supported by the Deutsche Forschungsgemeinschaft through the priority program SPP 1164, "Nano-and Microfluidics.''
000004229 520__ $$aThe recent development of microfluidic devices allows the investigation and manipulation of individual liquid microdroplets, capsules, and cells. The collective behavior of several red blood cells (RBCs) or microcapsules in narrow capillaries determines their flow-induced morphology, arrangement, and effective viscosity. Of fundamental interest here is the relation between the flow behavior and the elasticity and deformability of these objects, their long-range hydrodynamic interactions in microchannels, and thermal membrane undulations. We study these mechanisms in an in silico model, which combines a particle-based mesoscale simulation technique for the fluid hydrodynamics with a triangulated-membrane model. The 2 essential control parameters are the volume fraction of RBCs (the tube hematocrit, H(T)), and the flow velocity. Our simulations show that already at very low H(T), the deformability of RBCs implies a flow-induced cluster formation above a threshold flow velocity. At higher H(T) values, we predict 3 distinct phases: one consisting of disordered biconcave-disk-shaped RBCs, another with parachute-shaped RBCs aligned in a single file, and a third with slipper-shaped RBCs arranged as 2 parallel interdigitated rows. The deformation-mediated clustering and the arrangements of RBCs and microcapsules are relevant for many potential applications in physics, biology, and medicine, such as blood diagnosis and cell sorting in microfluidic devices.
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000004229 65320 $$2Author$$amesoscale hydrodynamics simulations
000004229 65320 $$2Author$$amicrofluidics
000004229 65320 $$2Author$$amicrocirculation
000004229 65320 $$2Author$$amembrane elasticity
000004229 65320 $$2Author$$aerythrocyte shapes
000004229 650_2 $$2MeSH$$aCapillaries
000004229 650_2 $$2MeSH$$aComputer Simulation
000004229 650_2 $$2MeSH$$aElasticity
000004229 650_2 $$2MeSH$$aErythrocytes
000004229 650_2 $$2MeSH$$aHematocrit
000004229 650_2 $$2MeSH$$aIndicator Dilution Techniques
000004229 650_2 $$2MeSH$$aLiposomes
000004229 650_2 $$2MeSH$$aMicrocirculation
000004229 650_2 $$2MeSH$$aMicrofluidic Analytical Techniques
000004229 650_2 $$2MeSH$$aPressure
000004229 650_2 $$2MeSH$$aRheology
000004229 650_7 $$00$$2NLM Chemicals$$aLiposomes
000004229 650_7 $$2WoSType$$aJ
000004229 7001_ $$0P:(DE-Juel1)VDB37578$$aNoguchi, H.$$b1$$uFZJ
000004229 7001_ $$0P:(DE-Juel1)130665$$aGompper, G.$$b2$$uFZJ
000004229 773__ $$0PERI:(DE-600)1461794-8$$a10.1073/pnas.0811484106$$gVol. 106, p. 6039 - 6043$$p6039 - 6043$$q106<6039 - 6043$$tProceedings of the National Academy of Sciences of the United States of America$$v106$$x0027-8424$$y2009
000004229 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669370
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000004229 9201_ $$0I:(DE-Juel1)VDB782$$d31.12.2010$$gIFF$$kIFF-2$$lTheorie der Weichen Materie und Biophysik$$x0
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