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000004267 0247_ $$2DOI$$a10.1002/hbm.20617
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000004267 084__ $$2WoS$$aNeurosciences
000004267 084__ $$2WoS$$aNeuroimaging
000004267 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000004267 1001_ $$0P:(DE-Juel1)VDB33810$$aHömke, L.$$b0$$uFZJ
000004267 245__ $$aAnalysis of lesions in patients with unilateral tactile agnosia using cytoarchitectonic probabilistic maps.
000004267 260__ $$aNew York, NY$$bWiley-Liss$$c2009
000004267 300__ $$a1444 - 1456
000004267 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000004267 440_0 $$02398$$aHuman Brain Mapping$$v30$$x1065-9471$$y5
000004267 500__ $$aRecord converted from VDB: 12.11.2012
000004267 520__ $$aWe propose a novel methodical approach to lesion analyses involving high-resolution MR images in combination with probabilistic cytoarchitectonic maps. 3D-MR images of the whole brain and the manually segmented lesion mask are spatially normalized to the reference brain of a stereotaxic probabilistic cytoarchitectonic atlas using a multiscale registration algorithm based on an elastic model. The procedure is demonstrated in three patients suffering from aperceptive tactile agnosia of the right hand due to chronic infarction of the left parietal cortex. Patient 1 presents a lesion in areas of the postcentral sulcus, Patient 3 in areas of the superior parietal lobule and adjacent intraparietal sulcus, and Patient 2 lesions in both regions. On the basis of neurobehavioral data, we conjectured degradation of sequential elementary sensory information processing within the postcentral gyrus, impeding texture recognition in Patients 1 and 2, and disturbed kinaesthetic information processing in the posterior parietal lobe, causing degraded shape recognition in the patients 2 and 3. The involvement of Brodmann areas 4a, 4p, 3a, 3b, 1, 2, and areas IP1 and IP2 of the intraparietal sulcus was assessed in terms of the voxel overlap between the spatially transformed lesion masks and the 50%-isocontours of the cytoarchitectonic maps. The disruption of the critical cytoarchitectonic areas and the impaired subfunctions, texture and shape recognition, relate as conjectured above. We conclude that the proposed method represents a promising approach to hypothesis-driven lesion analyses, yielding lesion-function correlates based on a cytoarchitectonic model. Finally, the lesion-function correlates are validated by functional imaging reference data.
000004267 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
000004267 588__ $$aDataset connected to Web of Science, Pubmed
000004267 650_2 $$2MeSH$$aAdult
000004267 650_2 $$2MeSH$$aAged
000004267 650_2 $$2MeSH$$aAgnosia: pathology
000004267 650_2 $$2MeSH$$aAgnosia: physiopathology
000004267 650_2 $$2MeSH$$aAlgorithms
000004267 650_2 $$2MeSH$$aBrain Mapping
000004267 650_2 $$2MeSH$$aDiscrimination (Psychology): physiology
000004267 650_2 $$2MeSH$$aFemale
000004267 650_2 $$2MeSH$$aFunctional Laterality: physiology
000004267 650_2 $$2MeSH$$aHumans
000004267 650_2 $$2MeSH$$aImaging, Three-Dimensional: methods
000004267 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000004267 650_2 $$2MeSH$$aMale
000004267 650_2 $$2MeSH$$aMiddle Aged
000004267 650_2 $$2MeSH$$aNeuropsychological Tests
000004267 650_2 $$2MeSH$$aParietal Lobe: pathology
000004267 650_2 $$2MeSH$$aPhysical Stimulation: methods
000004267 650_2 $$2MeSH$$aProbability
000004267 650_2 $$2MeSH$$aStereotaxic Techniques
000004267 650_2 $$2MeSH$$aTouch: physiology
000004267 650_7 $$2WoSType$$aJ
000004267 65320 $$2Author$$atactile agnosia
000004267 65320 $$2Author$$atexture recognition
000004267 65320 $$2Author$$ashape recognition
000004267 65320 $$2Author$$alesion analysis
000004267 65320 $$2Author$$acytoarchitectonic probabilistic maps
000004267 65320 $$2Author$$adouble dissociation
000004267 7001_ $$0P:(DE-Juel1)131631$$aAmunts, K.$$b1$$uFZJ
000004267 7001_ $$0P:(DE-HGF)0$$aBöning, L.$$b2
000004267 7001_ $$0P:(DE-HGF)0$$aFretz, C.$$b3
000004267 7001_ $$0P:(DE-HGF)0$$aBinkofski, F.$$b4
000004267 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b5$$uFZJ
000004267 7001_ $$0P:(DE-HGF)0$$aWeder, B.$$b6
000004267 773__ $$0PERI:(DE-600)1492703-2$$a10.1002/hbm.20617$$gVol. 30, p. 1444 - 1456$$p1444 - 1456$$q30<1444 - 1456$$tHuman brain mapping$$v30$$x1065-9471$$y2009
000004267 8567_ $$uhttp://dx.doi.org/10.1002/hbm.20617
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000004267 9141_ $$y2009
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