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@ARTICLE{Hmke:4267,
      author       = {Hömke, L. and Amunts, K. and Böning, L. and Fretz, C. and
                      Binkofski, F. and Zilles, K. and Weder, B.},
      title        = {{A}nalysis of lesions in patients with unilateral tactile
                      agnosia using cytoarchitectonic probabilistic maps.},
      journal      = {Human brain mapping},
      volume       = {30},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {PreJuSER-4267},
      pages        = {1444 - 1456},
      year         = {2009},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {We propose a novel methodical approach to lesion analyses
                      involving high-resolution MR images in combination with
                      probabilistic cytoarchitectonic maps. 3D-MR images of the
                      whole brain and the manually segmented lesion mask are
                      spatially normalized to the reference brain of a stereotaxic
                      probabilistic cytoarchitectonic atlas using a multiscale
                      registration algorithm based on an elastic model. The
                      procedure is demonstrated in three patients suffering from
                      aperceptive tactile agnosia of the right hand due to chronic
                      infarction of the left parietal cortex. Patient 1 presents a
                      lesion in areas of the postcentral sulcus, Patient 3 in
                      areas of the superior parietal lobule and adjacent
                      intraparietal sulcus, and Patient 2 lesions in both regions.
                      On the basis of neurobehavioral data, we conjectured
                      degradation of sequential elementary sensory information
                      processing within the postcentral gyrus, impeding texture
                      recognition in Patients 1 and 2, and disturbed kinaesthetic
                      information processing in the posterior parietal lobe,
                      causing degraded shape recognition in the patients 2 and 3.
                      The involvement of Brodmann areas 4a, 4p, 3a, 3b, 1, 2, and
                      areas IP1 and IP2 of the intraparietal sulcus was assessed
                      in terms of the voxel overlap between the spatially
                      transformed lesion masks and the $50\%-isocontours$ of the
                      cytoarchitectonic maps. The disruption of the critical
                      cytoarchitectonic areas and the impaired subfunctions,
                      texture and shape recognition, relate as conjectured above.
                      We conclude that the proposed method represents a promising
                      approach to hypothesis-driven lesion analyses, yielding
                      lesion-function correlates based on a cytoarchitectonic
                      model. Finally, the lesion-function correlates are validated
                      by functional imaging reference data.},
      keywords     = {Adult / Aged / Agnosia: pathology / Agnosia:
                      physiopathology / Algorithms / Brain Mapping /
                      Discrimination (Psychology): physiology / Female /
                      Functional Laterality: physiology / Humans / Imaging,
                      Three-Dimensional: methods / Magnetic Resonance Imaging:
                      methods / Male / Middle Aged / Neuropsychological Tests /
                      Parietal Lobe: pathology / Physical Stimulation: methods /
                      Probability / Stereotaxic Techniques / Touch: physiology / J
                      (WoSType)},
      cin          = {INM-2 / INM-1 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-1-20090406 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Neurosciences / Neuroimaging / Radiology, Nuclear Medicine
                      $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:18636551},
      UT           = {WOS:000265727600004},
      doi          = {10.1002/hbm.20617},
      url          = {https://juser.fz-juelich.de/record/4267},
}