Home > Publications database > Analysis of lesions in patients with unilateral tactile agnosia using cytoarchitectonic probabilistic maps. > print

001     4267
005     20180208203104.0
024 7 _ |2 pmid
|a pmid:18636551
024 7 _ |2 DOI
|a 10.1002/hbm.20617
024 7 _ |2 WOS
|a WOS:000265727600004
037 _ _ |a PreJuSER-4267
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Neurosciences
084 _ _ |2 WoS
|a Neuroimaging
084 _ _ |2 WoS
|a Radiology, Nuclear Medicine & Medical Imaging
100 1 _ |a Hömke, L.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB33810
245 _ _ |a Analysis of lesions in patients with unilateral tactile agnosia using cytoarchitectonic probabilistic maps.
260 _ _ |a New York, NY
|b Wiley-Liss
|c 2009
300 _ _ |a 1444 - 1456
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Human Brain Mapping
|x 1065-9471
|0 2398
|y 5
|v 30
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a We propose a novel methodical approach to lesion analyses involving high-resolution MR images in combination with probabilistic cytoarchitectonic maps. 3D-MR images of the whole brain and the manually segmented lesion mask are spatially normalized to the reference brain of a stereotaxic probabilistic cytoarchitectonic atlas using a multiscale registration algorithm based on an elastic model. The procedure is demonstrated in three patients suffering from aperceptive tactile agnosia of the right hand due to chronic infarction of the left parietal cortex. Patient 1 presents a lesion in areas of the postcentral sulcus, Patient 3 in areas of the superior parietal lobule and adjacent intraparietal sulcus, and Patient 2 lesions in both regions. On the basis of neurobehavioral data, we conjectured degradation of sequential elementary sensory information processing within the postcentral gyrus, impeding texture recognition in Patients 1 and 2, and disturbed kinaesthetic information processing in the posterior parietal lobe, causing degraded shape recognition in the patients 2 and 3. The involvement of Brodmann areas 4a, 4p, 3a, 3b, 1, 2, and areas IP1 and IP2 of the intraparietal sulcus was assessed in terms of the voxel overlap between the spatially transformed lesion masks and the 50%-isocontours of the cytoarchitectonic maps. The disruption of the critical cytoarchitectonic areas and the impaired subfunctions, texture and shape recognition, relate as conjectured above. We conclude that the proposed method represents a promising approach to hypothesis-driven lesion analyses, yielding lesion-function correlates based on a cytoarchitectonic model. Finally, the lesion-function correlates are validated by functional imaging reference data.
536 _ _ |a Funktion und Dysfunktion des Nervensystems
|c P33
|2 G:(DE-HGF)
|0 G:(DE-Juel1)FUEK409
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Adult
650 _ 2 |2 MeSH
|a Aged
650 _ 2 |2 MeSH
|a Agnosia: pathology
650 _ 2 |2 MeSH
|a Agnosia: physiopathology
650 _ 2 |2 MeSH
|a Algorithms
650 _ 2 |2 MeSH
|a Brain Mapping
650 _ 2 |2 MeSH
|a Discrimination (Psychology): physiology
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Functional Laterality: physiology
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Imaging, Three-Dimensional: methods
650 _ 2 |2 MeSH
|a Magnetic Resonance Imaging: methods
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Middle Aged
650 _ 2 |2 MeSH
|a Neuropsychological Tests
650 _ 2 |2 MeSH
|a Parietal Lobe: pathology
650 _ 2 |2 MeSH
|a Physical Stimulation: methods
650 _ 2 |2 MeSH
|a Probability
650 _ 2 |2 MeSH
|a Stereotaxic Techniques
650 _ 2 |2 MeSH
|a Touch: physiology
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a tactile agnosia
653 2 0 |2 Author
|a texture recognition
653 2 0 |2 Author
|a shape recognition
653 2 0 |2 Author
|a lesion analysis
653 2 0 |2 Author
|a cytoarchitectonic probabilistic maps
653 2 0 |2 Author
|a double dissociation
700 1 _ |a Amunts, K.
|b 1
|u FZJ
|0 P:(DE-Juel1)131631
700 1 _ |a Böning, L.
|b 2
|0 P:(DE-HGF)0
700 1 _ |a Fretz, C.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Binkofski, F.
|b 4
|0 P:(DE-HGF)0
700 1 _ |a Zilles, K.
|b 5
|u FZJ
|0 P:(DE-Juel1)131714
700 1 _ |a Weder, B.
|b 6
|0 P:(DE-HGF)0
773 _ _ |a 10.1002/hbm.20617
|g Vol. 30, p. 1444 - 1456
|p 1444 - 1456
|q 30<1444 - 1456
|0 PERI:(DE-600)1492703-2
|t Human brain mapping
|v 30
|y 2009
|x 1065-9471
856 7 _ |u http://dx.doi.org/10.1002/hbm.20617
909 C O |o oai:juser.fz-juelich.de:4267
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914 1 _ |y 2009
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981 _ _ |a I:(DE-Juel1)INM-1-20090406
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