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000042877 084__ $$2WoS$$aBiophysics
000042877 084__ $$2WoS$$aBiotechnology & Applied Microbiology
000042877 084__ $$2WoS$$aChemistry, Analytical
000042877 084__ $$2WoS$$aElectrochemistry
000042877 084__ $$2WoS$$aNanoscience & Nanotechnology
000042877 1001_ $$0P:(DE-Juel1)VDB19868$$aMeyburg, S.$$b0$$uFZJ
000042877 245__ $$aN-Channel Field Effect Transistors with Floating Gates for Extracellular Recordings
000042877 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2006
000042877 300__ $$a1037 - 1044
000042877 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000042877 520__ $$aA field-effect transistor (FET) for recording extracellular signals from electrogenic cells is presented. The so-called floating gate architecture combines a complementary metal oxide semiconductor (CMOS)-type n-channel transistor with an independent sensing area. This concept allows the transistor and sensing area to be optimised separately. The devices are robust and can be reused several times. The noise level of the devices was smaller than of comparable non-metallised gate FETs. In addition to the usual drift of FET devices, we observed a long-term drift that has to be controlled for future long-term measurements. The device performance for extracellular signal recording was tested using embryonic rat cardiac myocytes cultured on fibronectin-coated chips. The extracellular cell signals were recorded before and after the addition of the cardioactive isoproterenol. The signal shapes of the measured action potentials were comparable to the non-metallised gate FETs previously used in similar experiments. The fabrication of the devices involved the process steps of standard CMOS that were necessary to create n-channel transistors. The implementation of a complete CMOS process would facilitate the integration of the logical circuits necessary for signal pre-processing on a chip, which is a prerequisite for a greater number of sensor spots in future layouts.
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000042877 588__ $$aDataset connected to Web of Science, Pubmed
000042877 650_2 $$2MeSH$$aAction Potentials: physiology
000042877 650_2 $$2MeSH$$aAmplifiers, Electronic
000042877 650_2 $$2MeSH$$aAnimals
000042877 650_2 $$2MeSH$$aBiosensing Techniques: instrumentation
000042877 650_2 $$2MeSH$$aCells, Cultured
000042877 650_2 $$2MeSH$$aEquipment Design
000042877 650_2 $$2MeSH$$aEquipment Failure Analysis
000042877 650_2 $$2MeSH$$aMembrane Potentials: physiology
000042877 650_2 $$2MeSH$$aMicroelectrodes
000042877 650_2 $$2MeSH$$aMyocytes, Cardiac: physiology
000042877 650_2 $$2MeSH$$aRats
000042877 650_2 $$2MeSH$$aRats, Wistar
000042877 650_2 $$2MeSH$$aReproducibility of Results
000042877 650_2 $$2MeSH$$aSensitivity and Specificity
000042877 650_2 $$2MeSH$$aTransistors, Electronic
000042877 650_7 $$2WoSType$$aJ
000042877 65320 $$2Author$$afield-effect transistor (FET)
000042877 65320 $$2Author$$acomplementary metal oxide semiconductor (CMOS)
000042877 65320 $$2Author$$afloating gate
000042877 65320 $$2Author$$atitanium silicide (TiSi2)
000042877 65320 $$2Author$$aextracellular signal recording
000042877 65320 $$2Author$$arat cardiac myocyte
000042877 7001_ $$0P:(DE-Juel1)VDB5515$$aGoryll, M.$$b1$$uFZJ
000042877 7001_ $$0P:(DE-Juel1)VDB5547$$aMoers, J.$$b2$$uFZJ
000042877 7001_ $$0P:(DE-Juel1)VDB5728$$aIngebrandt, S.$$b3$$uFZJ
000042877 7001_ $$0P:(DE-Juel1)VDB11317$$aBöcker-Meffert, S.$$b4$$uFZJ
000042877 7001_ $$0P:(DE-Juel1)VDB975$$aLüth, H.$$b5$$uFZJ
000042877 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, A.$$b6$$uFZJ
000042877 773__ $$0PERI:(DE-600)1496379-6$$a10.1016/j.bios.2005.03.010$$gVol. 21, p. 1037 - 1044$$p1037 - 1044$$q21<1037 - 1044$$tBiosensors and bioelectronics$$v21$$x0956-5663$$y2006
000042877 8567_ $$uhttp://dx.doi.org/10.1016/j.bios.2005.03.010
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000042877 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000042877 9201_ $$0I:(DE-Juel1)VDB42$$d31.12.2006$$gISG$$kISG-2$$lInstitut für Bio- und Chemosensoren$$x0
000042877 9201_ $$0I:(DE-Juel1)VDB381$$d14.09.2008$$gCNI$$kCNI$$lCenter of Nanoelectronic Systems for Information Technology$$x1$$z381
000042877 9201_ $$0I:(DE-82)080009_20140620$$gJARA$$kJARA-FIT$$lJülich-Aachen Research Alliance - Fundamentals of Future Information Technology$$x2
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