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@ARTICLE{Meyburg:42877,
      author       = {Meyburg, S. and Goryll, M. and Moers, J. and Ingebrandt, S.
                      and Böcker-Meffert, S. and Lüth, H. and Offenhäusser, A.},
      title        = {{N}-{C}hannel {F}ield {E}ffect {T}ransistors with
                      {F}loating {G}ates for {E}xtracellular {R}ecordings},
      journal      = {Biosensors and bioelectronics},
      volume       = {21},
      issn         = {0956-5663},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-42877},
      pages        = {1037 - 1044},
      year         = {2006},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {A field-effect transistor (FET) for recording extracellular
                      signals from electrogenic cells is presented. The so-called
                      floating gate architecture combines a complementary metal
                      oxide semiconductor (CMOS)-type n-channel transistor with an
                      independent sensing area. This concept allows the transistor
                      and sensing area to be optimised separately. The devices are
                      robust and can be reused several times. The noise level of
                      the devices was smaller than of comparable non-metallised
                      gate FETs. In addition to the usual drift of FET devices, we
                      observed a long-term drift that has to be controlled for
                      future long-term measurements. The device performance for
                      extracellular signal recording was tested using embryonic
                      rat cardiac myocytes cultured on fibronectin-coated chips.
                      The extracellular cell signals were recorded before and
                      after the addition of the cardioactive isoproterenol. The
                      signal shapes of the measured action potentials were
                      comparable to the non-metallised gate FETs previously used
                      in similar experiments. The fabrication of the devices
                      involved the process steps of standard CMOS that were
                      necessary to create n-channel transistors. The
                      implementation of a complete CMOS process would facilitate
                      the integration of the logical circuits necessary for signal
                      pre-processing on a chip, which is a prerequisite for a
                      greater number of sensor spots in future layouts.},
      keywords     = {Action Potentials: physiology / Amplifiers, Electronic /
                      Animals / Biosensing Techniques: instrumentation / Cells,
                      Cultured / Equipment Design / Equipment Failure Analysis /
                      Membrane Potentials: physiology / Microelectrodes /
                      Myocytes, Cardiac: physiology / Rats / Rats, Wistar /
                      Reproducibility of Results / Sensitivity and Specificity /
                      Transistors, Electronic / J (WoSType)},
      cin          = {ISG-2 / CNI / JARA-FIT},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB42 / I:(DE-Juel1)VDB381 /
                      $I:(DE-82)080009_20140620$},
      pnm          = {Grundlagen für zukünftige Informationstechnologien},
      pid          = {G:(DE-Juel1)FUEK412},
      shelfmark    = {Biophysics / Biotechnology $\&$ Applied Microbiology /
                      Chemistry, Analytical / Electrochemistry / Nanoscience $\&$
                      Nanotechnology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:16029948},
      UT           = {WOS:000234644400007},
      doi          = {10.1016/j.bios.2005.03.010},
      url          = {https://juser.fz-juelich.de/record/42877},
}